Search for mutations near the alternatively spliced 8-amino-acid exon in the GABA(A) receptor γ2 subunit gene and lack of allelic association with alcoholism among four aboriginal groups and Han Chinese in Taiwan

Yun Pung P. Hsu; See Voon Seow; El Wei Loh; Yuan Chun Wang; Chiao Chicy Chen; Jeng Ming Yu; Andrew T.a. Cheng

doi:10.1016/S0169-328X(98)00053-9

Search for mutations near the alternatively spliced 8-amino-acid exon in the GABA(A) receptor γ2 subunit gene and lack of allelic association with alcoholism among four aboriginal groups and Han Chinese in Taiwan

Yun Pung P. Hsu, See Voon Seow, El Wei Loh, Yuan Chun Wang, Chiao Chicy Chen, Jeng Ming Yu, Andrew T.a. Cheng

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The alternatively spliced 8-amino-acid exon for the GABA(A) receptor γ2 subunit gene (GABRC2) has been postulated to mediate behavioral actions of alcohol. A rapid search for splice-junction mutations near the 8-amino-acid exon using restriction enzymes which normally recognize sequences near or in the exon gave negative results among 217 alcoholics in four aboriginal groups (Ami, Atayal, Bunun and Paiwan) and Han Chinese in Taiwan. The role of the GABRC2 gene in alcoholism was further assessed by a comparison of allelic frequencies revealed by a NciI RFLP between case and control groups. No significant association of alcohol dependence with GABRC2 alleles was observed. These results suggest that the GABRC2 gene probably does not play an essential role in predisposition to alcoholism in the sample population.

Original language	English
Pages (from-to)	284-286
Number of pages	3
Journal	Molecular Brain Research
Volume	56
Issue number	1-2
DOIs	https://doi.org/10.1016/S0169-328X(98)00053-9
Publication status	Published - May 1998
Externally published	Yes

Keywords

Alcoholism
Allelic association
Alternative splicing
GABA(A) receptor
Gamma 2 subunit
Mutation scan
Taiwanese aborigines

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0169-328X(98)00053-9

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Hsu, Y. P. P., Seow, S. V., Loh, E. W., Wang, Y. C., Chen, C. C., Yu, J. M., & Cheng, A. T. A. (1998). Search for mutations near the alternatively spliced 8-amino-acid exon in the GABA(A) receptor γ2 subunit gene and lack of allelic association with alcoholism among four aboriginal groups and Han Chinese in Taiwan. Molecular Brain Research, 56(1-2), 284-286. https://doi.org/10.1016/S0169-328X(98)00053-9

Search for mutations near the alternatively spliced 8-amino-acid exon in the GABA(A) receptor γ2 subunit gene and lack of allelic association with alcoholism among four aboriginal groups and Han Chinese in Taiwan. / Hsu, Yun Pung P.; Seow, See Voon; Loh, El Wei et al.
In: Molecular Brain Research, Vol. 56, No. 1-2, 05.1998, p. 284-286.

Research output: Contribution to journal › Article › peer-review

Hsu, YPP, Seow, SV, Loh, EW, Wang, YC, Chen, CC, Yu, JM & Cheng, ATA 1998, 'Search for mutations near the alternatively spliced 8-amino-acid exon in the GABA(A) receptor γ2 subunit gene and lack of allelic association with alcoholism among four aboriginal groups and Han Chinese in Taiwan', Molecular Brain Research, vol. 56, no. 1-2, pp. 284-286. https://doi.org/10.1016/S0169-328X(98)00053-9

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title = "Search for mutations near the alternatively spliced 8-amino-acid exon in the GABA(A) receptor γ2 subunit gene and lack of allelic association with alcoholism among four aboriginal groups and Han Chinese in Taiwan",

abstract = "The alternatively spliced 8-amino-acid exon for the GABA(A) receptor γ2 subunit gene (GABRC2) has been postulated to mediate behavioral actions of alcohol. A rapid search for splice-junction mutations near the 8-amino-acid exon using restriction enzymes which normally recognize sequences near or in the exon gave negative results among 217 alcoholics in four aboriginal groups (Ami, Atayal, Bunun and Paiwan) and Han Chinese in Taiwan. The role of the GABRC2 gene in alcoholism was further assessed by a comparison of allelic frequencies revealed by a NciI RFLP between case and control groups. No significant association of alcohol dependence with GABRC2 alleles was observed. These results suggest that the GABRC2 gene probably does not play an essential role in predisposition to alcoholism in the sample population.",

keywords = "Alcoholism, Allelic association, Alternative splicing, GABA(A) receptor, Gamma 2 subunit, Mutation scan, Taiwanese aborigines",

author = "Hsu, {Yun Pung P.} and Seow, {See Voon} and Loh, {El Wei} and Wang, {Yuan Chun} and Chen, {Chiao Chicy} and Yu, {Jeng Ming} and Cheng, {Andrew T.a.}",

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AU - Hsu, Yun Pung P.

AU - Seow, See Voon

AU - Loh, El Wei

AU - Wang, Yuan Chun

AU - Chen, Chiao Chicy

AU - Yu, Jeng Ming

AU - Cheng, Andrew T.a.

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N2 - The alternatively spliced 8-amino-acid exon for the GABA(A) receptor γ2 subunit gene (GABRC2) has been postulated to mediate behavioral actions of alcohol. A rapid search for splice-junction mutations near the 8-amino-acid exon using restriction enzymes which normally recognize sequences near or in the exon gave negative results among 217 alcoholics in four aboriginal groups (Ami, Atayal, Bunun and Paiwan) and Han Chinese in Taiwan. The role of the GABRC2 gene in alcoholism was further assessed by a comparison of allelic frequencies revealed by a NciI RFLP between case and control groups. No significant association of alcohol dependence with GABRC2 alleles was observed. These results suggest that the GABRC2 gene probably does not play an essential role in predisposition to alcoholism in the sample population.

AB - The alternatively spliced 8-amino-acid exon for the GABA(A) receptor γ2 subunit gene (GABRC2) has been postulated to mediate behavioral actions of alcohol. A rapid search for splice-junction mutations near the 8-amino-acid exon using restriction enzymes which normally recognize sequences near or in the exon gave negative results among 217 alcoholics in four aboriginal groups (Ami, Atayal, Bunun and Paiwan) and Han Chinese in Taiwan. The role of the GABRC2 gene in alcoholism was further assessed by a comparison of allelic frequencies revealed by a NciI RFLP between case and control groups. No significant association of alcohol dependence with GABRC2 alleles was observed. These results suggest that the GABRC2 gene probably does not play an essential role in predisposition to alcoholism in the sample population.

KW - Alcoholism

KW - Allelic association

KW - Alternative splicing

KW - GABA(A) receptor

KW - Gamma 2 subunit

KW - Mutation scan

KW - Taiwanese aborigines

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Search for mutations near the alternatively spliced 8-amino-acid exon in the GABA(A) receptor γ2 subunit gene and lack of allelic association with alcoholism among four aboriginal groups and Han Chinese in Taiwan

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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