Screening of anti-HTLV antibody in sera of normal individuals and patients with malignancies in Taiwan

Po Min Chen; Chang Fang Chiu; Tzeon Jye Chiou; Cheng Hwai Tzeng; Sun Tien Lin; Lih Shinn Wang; Yeh Lee; Kwang Yu Chien; Sien Shih Chang; Sakan Maeda; William A. Blattner; Benjamin N. Chiang; Melvyn F. Greaves

doi:10.1016/0145-2126(86)90065-2

Screening of anti-HTLV antibody in sera of normal individuals and patients with malignancies in Taiwan

Po Min Chen
, Chang Fang Chiu
, Tzeon Jye Chiou
, Cheng Hwai Tzeng
, Sun Tien Lin
, Lih Shinn Wang
, Yeh Lee
, Kwang Yu Chien
, Sien Shih Chang
, Sakan Maeda
, William A. Blattner
, Benjamin N. Chiang
, Melvyn F. Greaves

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

In the present study an immunofluorescence using KH-2 cells as target cells, has been developed for the screening of 1200 serum samples from normal individuals and 450 of cases from patients with various malignancies. The positive anti-HTLV-I antibody rate in the former group is 0.083%(1/1200) and while in the latter it is found to be 1.8%(8/450) (including 3 adult T-cell leukemia/lymphoma cases of the 92 hematopoietic and 5 of 358 non-hematopoietic malignancies). The differences between the two groups are found to be significantly different (p value is <0.0001). In addition to the 3 adult T-cell leukemia/lymphoma cases, the 5 seropositive cancer patients are of 5 different diseases. We have searched for the adult T-cell leukemia virus antigen and the p19 core protein in lymphoid cells of seropositive persons and the only positive cases were from cells of two proven adult T-cell leukemia (ATL) patients. Our results suggest that Taiwan is not an endemic area of adult T-cell leukemia virus and that KH-2 cells may be used for the detection of anti-HTLV-I antibodies.

Original language	English
Pages (from-to)	369-373
Number of pages	5
Journal	Leukemia Research
Volume	10
Issue number	4
DOIs	https://doi.org/10.1016/0145-2126(86)90065-2
Publication status	Published - 1986
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

anti-HTLV-I antibody
ATLV
hematologic malignancy
HTLV-I
KH-2 cell line
p24 core protein

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

Access to Document

10.1016/0145-2126(86)90065-2

Cite this

@article{e8fd242d94cf47d4af89228cb32c0258,

title = "Screening of anti-HTLV antibody in sera of normal individuals and patients with malignancies in Taiwan",

abstract = "In the present study an immunofluorescence using KH-2 cells as target cells, has been developed for the screening of 1200 serum samples from normal individuals and 450 of cases from patients with various malignancies. The positive anti-HTLV-I antibody rate in the former group is 0.083\%(1/1200) and while in the latter it is found to be 1.8\%(8/450) (including 3 adult T-cell leukemia/lymphoma cases of the 92 hematopoietic and 5 of 358 non-hematopoietic malignancies). The differences between the two groups are found to be significantly different (p value is <0.0001). In addition to the 3 adult T-cell leukemia/lymphoma cases, the 5 seropositive cancer patients are of 5 different diseases. We have searched for the adult T-cell leukemia virus antigen and the p19 core protein in lymphoid cells of seropositive persons and the only positive cases were from cells of two proven adult T-cell leukemia (ATL) patients. Our results suggest that Taiwan is not an endemic area of adult T-cell leukemia virus and that KH-2 cells may be used for the detection of anti-HTLV-I antibodies.",

keywords = "anti-HTLV-I antibody, ATLV, hematologic malignancy, HTLV-I, KH-2 cell line, p24 core protein",

author = "Chen, \{Po Min\} and Chiu, \{Chang Fang\} and Chiou, \{Tzeon Jye\} and Tzeng, \{Cheng Hwai\} and Lin, \{Sun Tien\} and Wang, \{Lih Shinn\} and Yeh Lee and Chien, \{Kwang Yu\} and Chang, \{Sien Shih\} and Sakan Maeda and Blattner, \{William A.\} and Chiang, \{Benjamin N.\} and Greaves, \{Melvyn F.\}",

note = "Funding Information: Acknowledgements--This work was supported by grants from the Clinical Research Center, Institute of Biomedical Sciences, Academia Sinica and National Science Council of the Republic of China.",

year = "1986",

doi = "10.1016/0145-2126(86)90065-2",

language = "English",

volume = "10",

pages = "369--373",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd",

number = "4",

}

TY - JOUR

T1 - Screening of anti-HTLV antibody in sera of normal individuals and patients with malignancies in Taiwan

AU - Chen, Po Min

AU - Chiu, Chang Fang

AU - Chiou, Tzeon Jye

AU - Tzeng, Cheng Hwai

AU - Lin, Sun Tien

AU - Wang, Lih Shinn

AU - Lee, Yeh

AU - Chien, Kwang Yu

AU - Chang, Sien Shih

AU - Maeda, Sakan

AU - Blattner, William A.

AU - Chiang, Benjamin N.

AU - Greaves, Melvyn F.

N1 - Funding Information: Acknowledgements--This work was supported by grants from the Clinical Research Center, Institute of Biomedical Sciences, Academia Sinica and National Science Council of the Republic of China.

PY - 1986

Y1 - 1986

N2 - In the present study an immunofluorescence using KH-2 cells as target cells, has been developed for the screening of 1200 serum samples from normal individuals and 450 of cases from patients with various malignancies. The positive anti-HTLV-I antibody rate in the former group is 0.083%(1/1200) and while in the latter it is found to be 1.8%(8/450) (including 3 adult T-cell leukemia/lymphoma cases of the 92 hematopoietic and 5 of 358 non-hematopoietic malignancies). The differences between the two groups are found to be significantly different (p value is <0.0001). In addition to the 3 adult T-cell leukemia/lymphoma cases, the 5 seropositive cancer patients are of 5 different diseases. We have searched for the adult T-cell leukemia virus antigen and the p19 core protein in lymphoid cells of seropositive persons and the only positive cases were from cells of two proven adult T-cell leukemia (ATL) patients. Our results suggest that Taiwan is not an endemic area of adult T-cell leukemia virus and that KH-2 cells may be used for the detection of anti-HTLV-I antibodies.

AB - In the present study an immunofluorescence using KH-2 cells as target cells, has been developed for the screening of 1200 serum samples from normal individuals and 450 of cases from patients with various malignancies. The positive anti-HTLV-I antibody rate in the former group is 0.083%(1/1200) and while in the latter it is found to be 1.8%(8/450) (including 3 adult T-cell leukemia/lymphoma cases of the 92 hematopoietic and 5 of 358 non-hematopoietic malignancies). The differences between the two groups are found to be significantly different (p value is <0.0001). In addition to the 3 adult T-cell leukemia/lymphoma cases, the 5 seropositive cancer patients are of 5 different diseases. We have searched for the adult T-cell leukemia virus antigen and the p19 core protein in lymphoid cells of seropositive persons and the only positive cases were from cells of two proven adult T-cell leukemia (ATL) patients. Our results suggest that Taiwan is not an endemic area of adult T-cell leukemia virus and that KH-2 cells may be used for the detection of anti-HTLV-I antibodies.

KW - anti-HTLV-I antibody

KW - ATLV

KW - hematologic malignancy

KW - HTLV-I

KW - KH-2 cell line

KW - p24 core protein

UR - https://www.scopus.com/pages/publications/0022571297

UR - https://www.scopus.com/pages/publications/0022571297#tab=citedBy

U2 - 10.1016/0145-2126(86)90065-2

DO - 10.1016/0145-2126(86)90065-2

M3 - Article

C2 - 2870219

AN - SCOPUS:0022571297

SN - 0145-2126

VL - 10

SP - 369

EP - 373

JO - Leukemia Research

JF - Leukemia Research

IS - 4

ER -

Screening of anti-HTLV antibody in sera of normal individuals and patients with malignancies in Taiwan

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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