Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro

Ray Ling Huang; Yu Ling Huang; Jun Chih Ou; Chien Chih Chen; Feng Lin Hsu; Chungming Chang

doi:10.1002/ptr.1167

Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro

Ray Ling Huang, Yu Ling Huang, Jun Chih Ou, Chien Chih Chen, Feng Lin Hsu, Chungming Chang

Graduate Institute of Pharmacognosy

Research output: Contribution to journal › Article › peer-review

109 Citations (Scopus)

Abstract

Using an HBV-producing cell line and inhibition of the expression of the HBsAg and HBeAg as antiviral indicators, a study was conducted on 25 compounds isolated from four Phyllanthus (Euphorbiaceae) plants, including P. amarus Schum. & Thonn., P. multiflorus Willd., P. tenellus Roxb. and P. virgatus Forst. f.. It was found that niranthin (1), nirtetralin (3), hinokinin (5) and geraniin (13) at the non-cytotoxic concentration of 50 μM, suppressed effectively both HBsAg and HBeAg expression, with the highest inhibition at 74.3%, 45.3%; 69.6%, 33.9%; 68.1%, 52.3%; 32.1%, 46.6%, respectively. Of these, niranthin (1) showed the best anti-HBsAg activity, while the most potent anti-HBeAg activity was observed with hinokinin (5).

Original language	English
Pages (from-to)	449-453
Number of pages	5
Journal	Phytotherapy Research
Volume	17
Issue number	5
DOIs	https://doi.org/10.1002/ptr.1167
Publication status	Published - May 2003

Keywords

Genus Phyllanthus
HBeAg
HBsAg
Hinokinin
Human hepatitis B virus
Niranthin

ASJC Scopus subject areas

Drug Discovery
Organic Chemistry
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ptr.1167

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title = "Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro",

abstract = "Using an HBV-producing cell line and inhibition of the expression of the HBsAg and HBeAg as antiviral indicators, a study was conducted on 25 compounds isolated from four Phyllanthus (Euphorbiaceae) plants, including P. amarus Schum. & Thonn., P. multiflorus Willd., P. tenellus Roxb. and P. virgatus Forst. f.. It was found that niranthin (1), nirtetralin (3), hinokinin (5) and geraniin (13) at the non-cytotoxic concentration of 50 μM, suppressed effectively both HBsAg and HBeAg expression, with the highest inhibition at 74.3%, 45.3%; 69.6%, 33.9%; 68.1%, 52.3%; 32.1%, 46.6%, respectively. Of these, niranthin (1) showed the best anti-HBsAg activity, while the most potent anti-HBeAg activity was observed with hinokinin (5).",

keywords = "Genus Phyllanthus, HBeAg, HBsAg, Hinokinin, Human hepatitis B virus, Niranthin",

author = "Huang, {Ray Ling} and Huang, {Yu Ling} and Ou, {Jun Chih} and Chen, {Chien Chih} and Hsu, {Feng Lin} and Chungming Chang",

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AU - Huang, Ray Ling

AU - Huang, Yu Ling

AU - Ou, Jun Chih

AU - Chen, Chien Chih

AU - Hsu, Feng Lin

AU - Chang, Chungming

PY - 2003/5

Y1 - 2003/5

N2 - Using an HBV-producing cell line and inhibition of the expression of the HBsAg and HBeAg as antiviral indicators, a study was conducted on 25 compounds isolated from four Phyllanthus (Euphorbiaceae) plants, including P. amarus Schum. & Thonn., P. multiflorus Willd., P. tenellus Roxb. and P. virgatus Forst. f.. It was found that niranthin (1), nirtetralin (3), hinokinin (5) and geraniin (13) at the non-cytotoxic concentration of 50 μM, suppressed effectively both HBsAg and HBeAg expression, with the highest inhibition at 74.3%, 45.3%; 69.6%, 33.9%; 68.1%, 52.3%; 32.1%, 46.6%, respectively. Of these, niranthin (1) showed the best anti-HBsAg activity, while the most potent anti-HBeAg activity was observed with hinokinin (5).

AB - Using an HBV-producing cell line and inhibition of the expression of the HBsAg and HBeAg as antiviral indicators, a study was conducted on 25 compounds isolated from four Phyllanthus (Euphorbiaceae) plants, including P. amarus Schum. & Thonn., P. multiflorus Willd., P. tenellus Roxb. and P. virgatus Forst. f.. It was found that niranthin (1), nirtetralin (3), hinokinin (5) and geraniin (13) at the non-cytotoxic concentration of 50 μM, suppressed effectively both HBsAg and HBeAg expression, with the highest inhibition at 74.3%, 45.3%; 69.6%, 33.9%; 68.1%, 52.3%; 32.1%, 46.6%, respectively. Of these, niranthin (1) showed the best anti-HBsAg activity, while the most potent anti-HBeAg activity was observed with hinokinin (5).

KW - Genus Phyllanthus

KW - HBeAg

KW - HBsAg

KW - Hinokinin

KW - Human hepatitis B virus

KW - Niranthin

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Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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