TY - JOUR
T1 - Screening for Frailty Using the FRAIL Scale in Older Cancer Survivors
T2 - A Cross-sectional Comparison With the Fried Phenotype
AU - Cheung, Denise Shuk Ting
AU - Ho, Mu Hsing
AU - Chau, Pui Hing
AU - Yu, Doris Sau Fung
AU - Chan, Wing Lok
AU - Soong, Sung Inda
AU - Woo, Jean
AU - Lin, Chia Chin
N1 - Publisher Copyright:
© 2024 Elsevier Inc.
PY - 2024
Y1 - 2024
N2 - Objectives: To examine the diagnostic performance of the FRAIL Scale for frailty screening with reference to the Fried phenotype and investigate its association with health outcomes in older cancer survivors. Data source: In this cross-sectional quantitative study, participants were post-treatment cancer survivors aged 65 or above. Measurements included the FRAIL Scale, Fried phenotype, Geriatric Depression Scale-15 item, Modified Barthel Inventory, and EORTC Core Quality of Life Questionnaire. Receiver operating characteristic curve analysis was performed to evaluate the diagnostic performance of the FRAIL Scale with reference to the Fried phenotype. Health outcomes associated with being frail as estimated by the FRAIL Scale and Fried phenotype were also examined using regressions. Results: Based on 293 older cancer survivors, the area under curve (AUC) of the FRAIL Scale was 0.79, and the optimal cut-off of 1 yielded a sensitivity of 92% and specificity of 41%. According to regression results, the FRAIL Scale was modified by adding an item on time since cancer treatment completion (AUC = 0.81), and using a cut-off of 2 for older cancer survivors, which yielded a sensitivity of 74% and specificity of 67%. The modified FRAIL Scale was associated with depressive symptoms, functional independence, fatigue, dyspnea, physical functioning, and role functioning. Conclusions: The modified FRAIL Scale is proposed for use in older cancer survivors, and a cut-off of 2 should be used. Implications for Nursing Practice: The modified FRAIL Scale can serve as a brief screening tool for identifying frailty among older cancer survivors in practice.
AB - Objectives: To examine the diagnostic performance of the FRAIL Scale for frailty screening with reference to the Fried phenotype and investigate its association with health outcomes in older cancer survivors. Data source: In this cross-sectional quantitative study, participants were post-treatment cancer survivors aged 65 or above. Measurements included the FRAIL Scale, Fried phenotype, Geriatric Depression Scale-15 item, Modified Barthel Inventory, and EORTC Core Quality of Life Questionnaire. Receiver operating characteristic curve analysis was performed to evaluate the diagnostic performance of the FRAIL Scale with reference to the Fried phenotype. Health outcomes associated with being frail as estimated by the FRAIL Scale and Fried phenotype were also examined using regressions. Results: Based on 293 older cancer survivors, the area under curve (AUC) of the FRAIL Scale was 0.79, and the optimal cut-off of 1 yielded a sensitivity of 92% and specificity of 41%. According to regression results, the FRAIL Scale was modified by adding an item on time since cancer treatment completion (AUC = 0.81), and using a cut-off of 2 for older cancer survivors, which yielded a sensitivity of 74% and specificity of 67%. The modified FRAIL Scale was associated with depressive symptoms, functional independence, fatigue, dyspnea, physical functioning, and role functioning. Conclusions: The modified FRAIL Scale is proposed for use in older cancer survivors, and a cut-off of 2 should be used. Implications for Nursing Practice: The modified FRAIL Scale can serve as a brief screening tool for identifying frailty among older cancer survivors in practice.
KW - Assessment
KW - Deficit accumulation
KW - Frailty
KW - Frailty phenotype
KW - Older cancer patients
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U2 - 10.1016/j.soncn.2024.151617
DO - 10.1016/j.soncn.2024.151617
M3 - Article
C2 - 38423822
AN - SCOPUS:85188205178
SN - 0749-2081
VL - 40
JO - Seminars in Oncology Nursing
JF - Seminars in Oncology Nursing
IS - 2
M1 - 151617
ER -