Abstract
Parkinsonism might precede, coincide, or follow the behavioral or language-predominant cognitive impairments characteristic of frontotemporal dementia (FTD). In this study, we analyze the hexanucleotide repeat expansions within C9orf72 gene in various parkinsonian syndromes because it is a recently identified important genetic cause of FTD. The expanded hexanucleotide repeat is only identified in our familial FTD patients but not in patients with predominant parkinsonism. The lack of association between abnormal C9orf72 repeat expansion and parkinsonian syndromes might imply pathogenic mechanisms other than tau or Lewy body pathology.
Original language | English |
---|---|
Pages (from-to) | 1311.e3-1311.e4 |
Journal | Neurobiology of Aging |
Volume | 34 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2013 |
Externally published | Yes |
Keywords
- C9orf72
- Corticobasal syndrome (CBS)
- Dementia with Lewy bodies (DLB)
- Frontotemporal dementia (FTD)
- GGGGCC hexanucleotide repeat expansion
- Parkinson's disease with dementia (PDD)
- Progressive supranuclear palsy (PSP)
ASJC Scopus subject areas
- Clinical Neurology
- General Neuroscience
- Ageing
- Developmental Biology
- Geriatrics and Gerontology