Abstract
Sponge-derived scalaranes are remarkable sesterterpenoids previously found to exhibit profound inhibitory effects against neutrophilic inflammation. In our current work, we constructed the metabolomic profile of marine sponge Lendenfeldia sp. for the first time using a tandem mass spectrometry (MS/MS) molecular networking approach. The results highlighted the rich chemical diversity of these scalaranes, motivating us to conduct further research to discover novel scalaranes targeting neutrophilic inflammation. MS-and NMR-assisted isolation and elucidation led to the discovery of seven new homoscalaranes, lendenfeldaranes K–Q (1–7), characterized by methylation at C-24, together with five known derivatives, lendenfeldarane B (8), 25-nor-24-methyl-12,24-dioxoscalar-16-en-22-oic acid (9), 24-methyl-12,24,25-trioxoscalar-16-en-22-oic acid (10), felixin B (11), and 23-hydroxy-20-methyldeoxoscalarin (12). Scalaranes 1–4 and 6–12 were assayed against superoxide anion generation and elastase release, which represented the neutrophilic inflammatory responses of respiratory burst and degranulation, respectively. The results indicated that 1–3 and 6–12 exhibited potential anti-inflammatory activities (IC50 for superoxide anion scavenging: 0.87~6.57 µM; IC50 for elastase release: 1.12~6.97 µM).
Original language | English |
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Article number | 561 |
Journal | Marine Drugs |
Volume | 19 |
Issue number | 10 |
DOIs | |
Publication status | Published - Sept 30 2021 |
Keywords
- Anti-neutrophilic inflammation
- Homoscalarane
- Lendenfeldia
- Molecular networking
ASJC Scopus subject areas
- Drug Discovery
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CCDC 1988979: Experimental Crystal Structure Determination
Peng, B. (Contributor), Lai, K. (Contributor), Lee, G. (Contributor), Yu, S. S. (Contributor), Duh, C. (Contributor), Su, J. (Contributor), Zheng, L. (Contributor), Hwang, T. (Contributor) & Sung, P. (Contributor), Cambridge Crystallographic Data Centre, 2021
DOI: 10.5517/ccdc.csd.cc24rpm7, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc24rpm7&sid=DataCite
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