Same-Day Bilateral Intravitreal Dexamethasone Implants for the Treatment of Diabetic Macular Edema

Tai Chi Lin, Po Chen Tseng, Tsui Kang Hsu, Hsin Wei Huang, Yi Ming Huang, Wen Jung Lo, Chen Yu Chao, Yu Chien Chung

Research output: Contribution to journalArticlepeer-review


Introduction: The aim of this study was to evaluate the outcomes and complications associated with the use of same-day bilateral intravitreal dexamethasone (DEX) implants for the treatment of diabetic macular edema (DME). Methods: This retrospective analysis of an open-label, multicenter, consecutive case series included 130 eyes of 65 patients with bilateral DME who were treated with intravitreal DEX implants. The patients were divided into two groups: a control group (comprising 40 eyes treated with an alternating unilateral regimen) and a study group (comprising 90 eyes treated with concomitant bilateral DEX implants). All patients were followed up monthly after implantation. The changes in best-corrected visual acuity (BCVA) and central retinal thickness (CRT) from baseline to sixth month after implantation, and ocular adverse effects such as intraocular pressure, cataract, and tolerability of bilateral implantation were reviewed. The primary endpoint was to assess the safety of the same-day bilateral treatment protocol. The secondary endpoints focused on evaluating the functional and anatomical changes associated with bilateral simultaneous or alternating implantations. Results: At 6 months after implantation, mean BCVA increased and CRT decreased in both groups. Moreover, no serious ocular adverse effects were observed. In addition, no differences were observed between the two groups in the number of patients who required extra follow-up visits or the number of extra visits made in addition to the treatment schedule. Conclusions: Same-day bilateral intravitreal DEX implants are associated with a low complication rate and are well tolerated by patients. This safe practice may optimize efficiency and reduce the burden on both the health-care system and patients, when used to treat bilateral DME.

Original languageEnglish
Pages (from-to)238-244
Number of pages7
Issue number3-4
Publication statusPublished - Nov 1 2023


  • Bilateral intravitreal implants
  • Dexamethasone
  • Diabetic macular edema
  • Same-day bilateral treatment

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems


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