Abstract

In the present study, we indicated that the detection of specific subtypes of circulating tumor microemboli (CTM) in post-operative patients could help predict cancer recurrence. By using conventional strategies for detection of non-small-cell lung cancer (NSCLC) circulating tumor cells, is significantly limited due to inherently heterogeneous and dynamic expression of EpCAM, and degradation of cytokeratins during epithelial-tomesenchymal transition. These lead to non-negligible false negative detection of “uncapturable and invisible” single CTCs. To solve the problem, we investigated the clinical significance of CTM subtypes, including single CTCs, multi-CTCs cluster, and WBC-CTCs cluster on SACA chip for studying cancer metastasis and recurrence in patients with lung adenocarcinoma.

Original languageEnglish
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1141-1142
Number of pages2
ISBN (Electronic)9781733419017
Publication statusPublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: Oct 4 2020Oct 9 2020

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period10/4/2010/9/20

Keywords

  • Circulating Tumor Cell Clusters
  • Immunotherapy
  • Non-small-cell lung cancer (NSCLC)

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering
  • General Chemistry
  • Control and Systems Engineering

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