S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors

Hsien Wei Yeh; Tzung Sheng Lin; Hsiao Wen Wang; Hou Wen Cheng; Der Zen Liu; Pi Hui Liang

doi:10.1039/c5ob01376c

S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors

Hsien Wei Yeh, Tzung Sheng Lin, Hsiao Wen Wang, Hou Wen Cheng, Der Zen Liu, Pi Hui Liang

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener 4 in both the virus neutralization assay and the hemagglutination inhibition assay.

Original language	English
Pages (from-to)	11518-11528
Number of pages	11
Journal	Organic and Biomolecular Chemistry
Volume	13
Issue number	47
DOIs	https://doi.org/10.1039/c5ob01376c
Publication status	Published - 2015

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1039/c5ob01376c

Cite this

@article{b663671e3d8d4bc8bcc0b10acf25b67d,

title = "S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors",

abstract = "An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener 4 in both the virus neutralization assay and the hemagglutination inhibition assay.",

author = "Yeh, \{Hsien Wei\} and Lin, \{Tzung Sheng\} and Wang, \{Hsiao Wen\} and Cheng, \{Hou Wen\} and Liu, \{Der Zen\} and Liang, \{Pi Hui\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",

year = "2015",

doi = "10.1039/c5ob01376c",

language = "English",

volume = "13",

pages = "11518--11528",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "47",

}

TY - JOUR

T1 - S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors

AU - Yeh, Hsien Wei

AU - Lin, Tzung Sheng

AU - Wang, Hsiao Wen

AU - Cheng, Hou Wen

AU - Liu, Der Zen

AU - Liang, Pi Hui

N1 - Publisher Copyright: © The Royal Society of Chemistry 2015.

PY - 2015

Y1 - 2015

N2 - An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener 4 in both the virus neutralization assay and the hemagglutination inhibition assay.

AB - An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener 4 in both the virus neutralization assay and the hemagglutination inhibition assay.

UR - https://www.scopus.com/pages/publications/84948405553

UR - https://www.scopus.com/inward/citedby.url?scp=84948405553&partnerID=8YFLogxK

U2 - 10.1039/c5ob01376c

DO - 10.1039/c5ob01376c

M3 - Article

C2 - 26464117

AN - SCOPUS:84948405553

SN - 1477-0520

VL - 13

SP - 11518

EP - 11528

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 47

ER -

S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this