S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors

Hsien Wei Yeh; Tzung Sheng Lin; Hsiao Wen Wang; Hou Wen Cheng; Der Zen Liu; Pi Hui Liang

doi:10.1039/c5ob01376c

S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors

Hsien Wei Yeh
, Tzung Sheng Lin
, Hsiao Wen Wang
, Hou Wen Cheng
, Der Zen Liu
, Pi Hui Liang

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener 4 in both the virus neutralization assay and the hemagglutination inhibition assay.

Original language	English
Pages (from-to)	11518-11528
Number of pages	11
Journal	Organic and Biomolecular Chemistry
Volume	13
Issue number	47
DOIs	https://doi.org/10.1039/c5ob01376c
Publication status	Published - 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c5ob01376c

Cite this

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abstract = "An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener 4 in both the virus neutralization assay and the hemagglutination inhibition assay.",

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T1 - S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors

AU - Yeh, Hsien Wei

AU - Lin, Tzung Sheng

AU - Wang, Hsiao Wen

AU - Cheng, Hou Wen

AU - Liu, Der Zen

AU - Liang, Pi Hui

N1 - Publisher Copyright: © The Royal Society of Chemistry 2015.

PY - 2015

Y1 - 2015

N2 - An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener 4 in both the virus neutralization assay and the hemagglutination inhibition assay.

AB - An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener 4 in both the virus neutralization assay and the hemagglutination inhibition assay.

UR - https://www.scopus.com/pages/publications/84948405553

UR - https://www.scopus.com/pages/publications/84948405553#tab=citedBy

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DO - 10.1039/c5ob01376c

M3 - Article

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AN - SCOPUS:84948405553

SN - 1477-0520

VL - 13

SP - 11518

EP - 11528

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 47

ER -

S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors

Abstract

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ASJC Scopus subject areas

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