TY - JOUR
T1 - rpoB genotypes of Mycobacterium tuberculosis Beijing family isolates from East Asian countries
AU - Qian, Lishi
AU - Abe, Chiyoji
AU - Lin, Tao Ping
AU - Yu, Ming Chih
AU - Cho, Sang Nae
AU - Wang, Sumin
AU - Douglas, James T.
PY - 2002
Y1 - 2002
N2 - The 81-bp region of the rpoB gene in 66 Rif Mycobacterium tuberculosis isolates from China, Japan, Korea, and Taiwan was analyzed. Twelve single-nucleotide substitutions in the rpoB gene were detected. The most prevalent mutations were at Ser-531 (52%), Asp-516 (17%), and His-526 (11%). Mutations were not found in seven (11%) of the isolates. Higher mutation rates in 50 Beijing family isolates were found than in other isolates for mutations at Asp-516 (18 and 12.5%, respectively) and His-526 (12 and 6.3%, respectively). The different rates of mutation may reflect the choice of rifamycin analogs.
AB - The 81-bp region of the rpoB gene in 66 Rif Mycobacterium tuberculosis isolates from China, Japan, Korea, and Taiwan was analyzed. Twelve single-nucleotide substitutions in the rpoB gene were detected. The most prevalent mutations were at Ser-531 (52%), Asp-516 (17%), and His-526 (11%). Mutations were not found in seven (11%) of the isolates. Higher mutation rates in 50 Beijing family isolates were found than in other isolates for mutations at Asp-516 (18 and 12.5%, respectively) and His-526 (12 and 6.3%, respectively). The different rates of mutation may reflect the choice of rifamycin analogs.
UR - http://www.scopus.com/inward/record.url?scp=0036192476&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036192476&partnerID=8YFLogxK
U2 - 10.1128/JCM.40.3.1091-1094.2002
DO - 10.1128/JCM.40.3.1091-1094.2002
M3 - Article
C2 - 11880449
AN - SCOPUS:0036192476
SN - 0095-1137
VL - 40
SP - 1091
EP - 1094
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 3
ER -