Roles of Resveratrol as Signaling Sensor and Gatekeeper

Ya-Jung Shih; Yi Ru Chen; Kuan Wang; Jacqueline Whang-Peng; Heng Yuan Tang; Hung-Yun Lin; Paul J. Davis

Roles of Resveratrol as Signaling Sensor and Gatekeeper

Ya-Jung Shih, Yi Ru Chen, Kuan Wang, Jacqueline Whang-Peng, Heng Yuan Tang, Hung-Yun Lin, Paul J. Davis

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Abstract

Resveratrol (trans-3,4′,5-trihydroxystilbene) is a natural phytoalexin that has pharmacological effects on several human diseases: cancer, coronary artery disease and neurodegenerative diseases. Many studies have reported the application of resveratrol as a preventive drug for these important conditions. In addition, recent reports indicate that resveratrol may also increase the lifespan of yeast and fruit flies. The positive effects of resveratrol have largely been demonstrated in vitro or in animal studies, with only limited and inconsistent effects reported in clinical studies. In addition, roles of resveratrol as signaling sensor and gatekeeper are still not clear. In this chapter, we will summarize a group of potentially important roles for resveratrol in diverse biological systems, particularly in metabolism and in cancer.

Original language	English
Title of host publication	Resveratrol: State-of-the-Art Science and Health Applications
Publisher	World Scientific Publishing Co.
Pages	115-144
Publication status	Published - 2018

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https://www.worldscientific.com/doi/abs/10.1142/9789813270916_0004

Cite this

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title = "Roles of Resveratrol as Signaling Sensor and Gatekeeper",

abstract = "Resveratrol (trans-3,4′,5-trihydroxystilbene) is a natural phytoalexin that has pharmacological effects on several human diseases: cancer, coronary artery disease and neurodegenerative diseases. Many studies have reported the application of resveratrol as a preventive drug for these important conditions. In addition, recent reports indicate that resveratrol may also increase the lifespan of yeast and fruit flies. The positive effects of resveratrol have largely been demonstrated in vitro or in animal studies, with only limited and inconsistent effects reported in clinical studies. In addition, roles of resveratrol as signaling sensor and gatekeeper are still not clear. In this chapter, we will summarize a group of potentially important roles for resveratrol in diverse biological systems, particularly in metabolism and in cancer.",

author = "Ya-Jung Shih and Chen, {Yi Ru} and Kuan Wang and Jacqueline Whang-Peng and Tang, {Heng Yuan} and Hung-Yun Lin and Davis, {Paul J.}",

year = "2018",

language = "English",

pages = "115--144",

booktitle = "Resveratrol: State-of-the-Art Science and Health Applications",

publisher = "World Scientific Publishing Co.",

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TY - CHAP

T1 - Roles of Resveratrol as Signaling Sensor and Gatekeeper

AU - Shih, Ya-Jung

AU - Chen, Yi Ru

AU - Wang, Kuan

AU - Whang-Peng, Jacqueline

AU - Tang, Heng Yuan

AU - Lin, Hung-Yun

AU - Davis, Paul J.

PY - 2018

Y1 - 2018

N2 - Resveratrol (trans-3,4′,5-trihydroxystilbene) is a natural phytoalexin that has pharmacological effects on several human diseases: cancer, coronary artery disease and neurodegenerative diseases. Many studies have reported the application of resveratrol as a preventive drug for these important conditions. In addition, recent reports indicate that resveratrol may also increase the lifespan of yeast and fruit flies. The positive effects of resveratrol have largely been demonstrated in vitro or in animal studies, with only limited and inconsistent effects reported in clinical studies. In addition, roles of resveratrol as signaling sensor and gatekeeper are still not clear. In this chapter, we will summarize a group of potentially important roles for resveratrol in diverse biological systems, particularly in metabolism and in cancer.

AB - Resveratrol (trans-3,4′,5-trihydroxystilbene) is a natural phytoalexin that has pharmacological effects on several human diseases: cancer, coronary artery disease and neurodegenerative diseases. Many studies have reported the application of resveratrol as a preventive drug for these important conditions. In addition, recent reports indicate that resveratrol may also increase the lifespan of yeast and fruit flies. The positive effects of resveratrol have largely been demonstrated in vitro or in animal studies, with only limited and inconsistent effects reported in clinical studies. In addition, roles of resveratrol as signaling sensor and gatekeeper are still not clear. In this chapter, we will summarize a group of potentially important roles for resveratrol in diverse biological systems, particularly in metabolism and in cancer.

M3 - Chapter (peer-reviewed)

SP - 115

EP - 144

BT - Resveratrol: State-of-the-Art Science and Health Applications

PB - World Scientific Publishing Co.

ER -

Roles of Resveratrol as Signaling Sensor and Gatekeeper

Abstract

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