Roles of hepatic progenitor cells activation, ductular reaction proliferation and notch signaling in morbid obesity

Phui Ly Liew; Weu Wang; Yi Chih Lee; Ming Te Huang; Wei Jei Lee

doi:10.5754/hge10861

Roles of hepatic progenitor cells activation, ductular reaction proliferation and notch signaling in morbid obesity

Phui Ly Liew, Weu Wang, Yi Chih Lee, Ming Te Huang, Wei Jei Lee

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Background/Aims: Hepatic progenitor cells (HPCs) activation, proliferative ductular reaction (DR), replicative arrest and Notch signaling have been demonstrated in a variety of human liver diseases. The relationships are poorly understood in morbid obesity. We investigated factors responsible for the HPCs/DR, replicative arrest and Notch signaling in non-NASH and NASH groups. Methodology: Cytokeratin 7 (and 19), p21, CD34, Ki67 and different Notch receptors and ligands immunohistochemical stained biopsies from morbid obese patients with non-NASH (n=10) and NASH (n=25) were studied. These results were correlated with clinicopathological variables. Results: NASH patients presented with abnormal liver function tests and had higher HbA1c percentage. Strong association between HPCs and DR was seen (r=0.785, p

Original language	English
Pages (from-to)	1921-1927
Number of pages	7
Journal	Hepato-Gastroenterology
Volume	59
Issue number	118
DOIs	https://doi.org/10.5754/hge10861
Publication status	Published - Sept 2012

Keywords

Ductular reaction
Hepatic progenitor cells
Liver disease
Morbid obesity
Notch signaling

ASJC Scopus subject areas

Gastroenterology
Hepatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.5754/hge10861

Cite this

@article{cc6aa24d52b1498f850b315a0373651e,

title = "Roles of hepatic progenitor cells activation, ductular reaction proliferation and notch signaling in morbid obesity",

abstract = "Background/Aims: Hepatic progenitor cells (HPCs) activation, proliferative ductular reaction (DR), replicative arrest and Notch signaling have been demonstrated in a variety of human liver diseases. The relationships are poorly understood in morbid obesity. We investigated factors responsible for the HPCs/DR, replicative arrest and Notch signaling in non-NASH and NASH groups. Methodology: Cytokeratin 7 (and 19), p21, CD34, Ki67 and different Notch receptors and ligands immunohistochemical stained biopsies from morbid obese patients with non-NASH (n=10) and NASH (n=25) were studied. These results were correlated with clinicopathological variables. Results: NASH patients presented with abnormal liver function tests and had higher HbA1c percentage. Strong association between HPCs and DR was seen (r=0.785, p",

keywords = "Ductular reaction, Hepatic progenitor cells, Liver disease, Morbid obesity, Notch signaling",

author = "Liew, {Phui Ly} and Weu Wang and Lee, {Yi Chih} and Huang, {Ming Te} and Lee, {Wei Jei}",

year = "2012",

month = sep,

doi = "10.5754/hge10861",

language = "English",

volume = "59",

pages = "1921--1927",

journal = "Hepato-Gastroenterology",

issn = "0172-6390",

publisher = "H.G.E. Update Medical Publishing Ltd.",

number = "118",

}

TY - JOUR

T1 - Roles of hepatic progenitor cells activation, ductular reaction proliferation and notch signaling in morbid obesity

AU - Liew, Phui Ly

AU - Wang, Weu

AU - Lee, Yi Chih

AU - Huang, Ming Te

AU - Lee, Wei Jei

PY - 2012/9

Y1 - 2012/9

N2 - Background/Aims: Hepatic progenitor cells (HPCs) activation, proliferative ductular reaction (DR), replicative arrest and Notch signaling have been demonstrated in a variety of human liver diseases. The relationships are poorly understood in morbid obesity. We investigated factors responsible for the HPCs/DR, replicative arrest and Notch signaling in non-NASH and NASH groups. Methodology: Cytokeratin 7 (and 19), p21, CD34, Ki67 and different Notch receptors and ligands immunohistochemical stained biopsies from morbid obese patients with non-NASH (n=10) and NASH (n=25) were studied. These results were correlated with clinicopathological variables. Results: NASH patients presented with abnormal liver function tests and had higher HbA1c percentage. Strong association between HPCs and DR was seen (r=0.785, p

AB - Background/Aims: Hepatic progenitor cells (HPCs) activation, proliferative ductular reaction (DR), replicative arrest and Notch signaling have been demonstrated in a variety of human liver diseases. The relationships are poorly understood in morbid obesity. We investigated factors responsible for the HPCs/DR, replicative arrest and Notch signaling in non-NASH and NASH groups. Methodology: Cytokeratin 7 (and 19), p21, CD34, Ki67 and different Notch receptors and ligands immunohistochemical stained biopsies from morbid obese patients with non-NASH (n=10) and NASH (n=25) were studied. These results were correlated with clinicopathological variables. Results: NASH patients presented with abnormal liver function tests and had higher HbA1c percentage. Strong association between HPCs and DR was seen (r=0.785, p

KW - Ductular reaction

KW - Hepatic progenitor cells

KW - Liver disease

KW - Morbid obesity

KW - Notch signaling

UR - http://www.scopus.com/inward/record.url?scp=84867702988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867702988&partnerID=8YFLogxK

U2 - 10.5754/hge10861

DO - 10.5754/hge10861

M3 - Article

C2 - 22819913

AN - SCOPUS:84867702988

SN - 0172-6390

VL - 59

SP - 1921

EP - 1927

JO - Hepato-Gastroenterology

JF - Hepato-Gastroenterology

IS - 118

ER -

Roles of hepatic progenitor cells activation, ductular reaction proliferation and notch signaling in morbid obesity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this