Abstract
Background/Aims: Hepatic progenitor cells (HPCs) activation, proliferative ductular reaction (DR), replicative arrest and Notch signaling have been demonstrated in a variety of human liver diseases. The relationships are poorly understood in morbid obesity. We investigated factors responsible for the HPCs/DR, replicative arrest and Notch signaling in non-NASH and NASH groups. Methodology: Cytokeratin 7 (and 19), p21, CD34, Ki67 and different Notch receptors and ligands immunohistochemical stained biopsies from morbid obese patients with non-NASH (n=10) and NASH (n=25) were studied. These results were correlated with clinicopathological variables. Results: NASH patients presented with abnormal liver function tests and had higher HbA1c percentage. Strong association between HPCs and DR was seen (r=0.785, p
Original language | English |
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Pages (from-to) | 1921-1927 |
Number of pages | 7 |
Journal | Hepato-Gastroenterology |
Volume | 59 |
Issue number | 118 |
DOIs | |
Publication status | Published - Sept 2012 |
Keywords
- Ductular reaction
- Hepatic progenitor cells
- Liver disease
- Morbid obesity
- Notch signaling
ASJC Scopus subject areas
- Gastroenterology
- Hepatology