Roles of Aldolase Family Genes in Human Cancers and Diseases

Yu Chan Chang; Yi Chieh Yang; Chia Ping Tien; Chih Jen Yang; Michael Hsiao

doi:10.1016/j.tem.2018.05.003

Roles of Aldolase Family Genes in Human Cancers and Diseases

Yu Chan Chang, Yi Chieh Yang, Chia Ping Tien, Chih Jen Yang, Michael Hsiao

Research output: Contribution to journal › Review article › peer-review

124 Citations (Scopus)

Abstract

The aldolase family members involved in metabolism and glycolysis are present in three isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human tissues, and aberrant expression has been observed in several human diseases and cancer types. However, non-enzymatic functions through protein–protein interactions or epigenetic modifications have been reported in recent years. Using high-throughput screening and -omics database integration, aldolase has been validated as an independent clinical prognostic marker of human cancers. Therefore, the aim of this review was to provide potential clinical value from in silico predictions and also summarize well-known signaling axes or phenotypes in various cancer types. Finally, we discuss the role of aldolase in the treatment of human diseases and cancers.

Original language	English
Pages (from-to)	549-559
Number of pages	11
Journal	Trends in Endocrinology and Metabolism
Volume	29
Issue number	8
DOIs	https://doi.org/10.1016/j.tem.2018.05.003
Publication status	Published - Aug 2018

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tem.2018.05.003

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title = "Roles of Aldolase Family Genes in Human Cancers and Diseases",

abstract = "The aldolase family members involved in metabolism and glycolysis are present in three isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human tissues, and aberrant expression has been observed in several human diseases and cancer types. However, non-enzymatic functions through protein–protein interactions or epigenetic modifications have been reported in recent years. Using high-throughput screening and -omics database integration, aldolase has been validated as an independent clinical prognostic marker of human cancers. Therefore, the aim of this review was to provide potential clinical value from in silico predictions and also summarize well-known signaling axes or phenotypes in various cancer types. Finally, we discuss the role of aldolase in the treatment of human diseases and cancers.",

author = "Chang, {Yu Chan} and Yang, {Yi Chieh} and Tien, {Chia Ping} and Yang, {Chih Jen} and Michael Hsiao",

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year = "2018",

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volume = "29",

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T1 - Roles of Aldolase Family Genes in Human Cancers and Diseases

AU - Chang, Yu Chan

AU - Yang, Yi Chieh

AU - Tien, Chia Ping

AU - Yang, Chih Jen

AU - Hsiao, Michael

PY - 2018/8

Y1 - 2018/8

N2 - The aldolase family members involved in metabolism and glycolysis are present in three isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human tissues, and aberrant expression has been observed in several human diseases and cancer types. However, non-enzymatic functions through protein–protein interactions or epigenetic modifications have been reported in recent years. Using high-throughput screening and -omics database integration, aldolase has been validated as an independent clinical prognostic marker of human cancers. Therefore, the aim of this review was to provide potential clinical value from in silico predictions and also summarize well-known signaling axes or phenotypes in various cancer types. Finally, we discuss the role of aldolase in the treatment of human diseases and cancers.

AB - The aldolase family members involved in metabolism and glycolysis are present in three isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human tissues, and aberrant expression has been observed in several human diseases and cancer types. However, non-enzymatic functions through protein–protein interactions or epigenetic modifications have been reported in recent years. Using high-throughput screening and -omics database integration, aldolase has been validated as an independent clinical prognostic marker of human cancers. Therefore, the aim of this review was to provide potential clinical value from in silico predictions and also summarize well-known signaling axes or phenotypes in various cancer types. Finally, we discuss the role of aldolase in the treatment of human diseases and cancers.

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Roles of Aldolase Family Genes in Human Cancers and Diseases

Abstract

ASJC Scopus subject areas

UN SDGs

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