Role of PVAT in obesity-related cardiovascular disease through the buffering activity of ATF3

Hsiao Fen Li, Hsin Tzu Liu, Po Yi Chen, Heng Lin, Tzu Ling Tseng

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Thoracic aortic perivascular adipose tissue (PVAT) is an adipose organ exhibiting similarities to brown adipose tissue (BAT), including cellular morphology and thermogenic gene expression. However, whether the PVAT phenotype is indistinguishable from the BAT phenotype in physiological vasculature remains unclear. We demonstrated that PVAT is distinguishable from classical BAT, given its specific vessel-tone-controlling function. Activating transcription factor 3 (ATF3) is a key factor in hypertension. Compared with wild-type mice, ATF3-deficient (ATF3−/−) mice fed a high-fat diet exhibited elevated mean arterial pressure, increased monocyte chemoattractant protein-1 expression and hypertrophy, plus abnormal fatty tissue accumulation in the thoracic aortic PVAT, and enhanced vascular wall tension and vasoconstrictive responses of potassium chloride, U46619, and norepinephrine in isolated aortic rings, which were restored after administration of adeno-associated ATF3 vector. We suggest that PVAT, not BAT, modulates obesity-related vascular dysfunction. ATF3 within PVAT could provide new insights into the pathophysiology of obesity-related cardiovascular diseases.

Original languageEnglish
Article number105631
Issue number12
Publication statusPublished - Dec 22 2022


  • Cardiovascular medicine
  • Molecular biology

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Role of PVAT in obesity-related cardiovascular disease through the buffering activity of ATF3'. Together they form a unique fingerprint.

Cite this