Abstract
In this study, the possible role of oxygen-derived free radicals in cysteamine-induced duodenal ulcers in rats was investigated. Separate groups of rats were treated with 350 mg/kg cysteamine subcutaneously. Superoxide dismutase (SOD) activity and thiobarbituric acid (TBA) reactants in the duodenal mucosa were analyzed one, three, six, 12 and 24 hours after treatment, respectively. Cu,Zn-SOD activity significantly decreased from 41.79 ± 3.53 NU/mg protein to 29.56 ± 3.62, 27.23 ± 3.02 and 24.64 ± 3.07 NU/mg protein at three, six and 12 hours, respectively. TBA reactants, indicators of tissue injury by oxygen-derived free radicals, significantly increased from 0.18 ± 0.10 nmol/mg protein to 1.31 ± 0.12 and 1.57 ± 0.09 nmol/mg protein at six and 12 hours after cysteamine treatment, respectively. We conclude that an increase of oxygen-derived free radicals and a decrease of Cu,Zn-SOD activity in the duodenal mucosa may be involved in the pathogenesis of cysteamine-induced duodenal ulcers in rats.
| Original language | English |
|---|---|
| Pages (from-to) | 11-14 |
| Number of pages | 4 |
| Journal | Journal of the Formosan Medical Association |
| Volume | 93 |
| Issue number | 1 |
| Publication status | Published - 1994 |
Keywords
- cysteamine
- duodenal ulcer
- lipid peroxidation
- oxygen-derived free radicals
- superoxide dismutase
ASJC Scopus subject areas
- General Medicine