Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer

C. W. Lin; S. W. Tseng; S. F. Yang; C. P. Ko; C. H. Lin; L. H. Wei; M. H. Chien; Y. S. Hsieh

doi:10.1111/j.1601-0825.2012.01938.x

Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer

C. W. Lin, S. W. Tseng, S. F. Yang, C. P. Ko, C. H. Lin, L. H. Wei, M. H. Chien, Y. S. Hsieh

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Objectives: Recent evidence demonstrated that lipocalin (LCN)2 is induced in many types of human cancer, while the detection of its complex with matrix metalloproteinase (MMP)-9 is correlated with the cancer disease status. We attempted to evaluate plasma expressions of LCN2, MMP-9, and their complex (LCN2/MMP-9) during the diagnostic work-up of patients with oral squamous cell carcinoma (OSCC) and investigated their correlations with disease progression. Methods: In total, 195 patients with OSCC and 81 healthy controls were recruited. Expression levels of LCN2, MMP-9, and LCN2/MMP-9 were determined with immunoenzymatic assays. Results: Patients with OSCC exhibited significantly higher levels of LCN2, MMP-9, and LCN2/MMP-9 compared with healthy controls (LCN2: P

Original language	English
Pages (from-to)	734-740
Number of pages	7
Journal	Oral Diseases
Volume	18
Issue number	8
DOIs	https://doi.org/10.1111/j.1601-0825.2012.01938.x
Publication status	Published - Nov 2012

Keywords

Lipocalin 2
Matrix metalloproteinase-9
Oral squamous cell carcinoma

ASJC Scopus subject areas

General Dentistry
Otorhinolaryngology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1601-0825.2012.01938.x

Cite this

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title = "Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer",

abstract = "Objectives: Recent evidence demonstrated that lipocalin (LCN)2 is induced in many types of human cancer, while the detection of its complex with matrix metalloproteinase (MMP)-9 is correlated with the cancer disease status. We attempted to evaluate plasma expressions of LCN2, MMP-9, and their complex (LCN2/MMP-9) during the diagnostic work-up of patients with oral squamous cell carcinoma (OSCC) and investigated their correlations with disease progression. Methods: In total, 195 patients with OSCC and 81 healthy controls were recruited. Expression levels of LCN2, MMP-9, and LCN2/MMP-9 were determined with immunoenzymatic assays. Results: Patients with OSCC exhibited significantly higher levels of LCN2, MMP-9, and LCN2/MMP-9 compared with healthy controls (LCN2: P",

keywords = "Lipocalin 2, Matrix metalloproteinase-9, Oral squamous cell carcinoma",

author = "Lin, {C. W.} and Tseng, {S. W.} and Yang, {S. F.} and Ko, {C. P.} and Lin, {C. H.} and Wei, {L. H.} and Chien, {M. H.} and Hsieh, {Y. S.}",

year = "2012",

month = nov,

doi = "10.1111/j.1601-0825.2012.01938.x",

language = "English",

volume = "18",

pages = "734--740",

journal = "Oral Diseases",

issn = "1354-523X",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer

AU - Lin, C. W.

AU - Tseng, S. W.

AU - Yang, S. F.

AU - Ko, C. P.

AU - Lin, C. H.

AU - Wei, L. H.

AU - Chien, M. H.

AU - Hsieh, Y. S.

PY - 2012/11

Y1 - 2012/11

N2 - Objectives: Recent evidence demonstrated that lipocalin (LCN)2 is induced in many types of human cancer, while the detection of its complex with matrix metalloproteinase (MMP)-9 is correlated with the cancer disease status. We attempted to evaluate plasma expressions of LCN2, MMP-9, and their complex (LCN2/MMP-9) during the diagnostic work-up of patients with oral squamous cell carcinoma (OSCC) and investigated their correlations with disease progression. Methods: In total, 195 patients with OSCC and 81 healthy controls were recruited. Expression levels of LCN2, MMP-9, and LCN2/MMP-9 were determined with immunoenzymatic assays. Results: Patients with OSCC exhibited significantly higher levels of LCN2, MMP-9, and LCN2/MMP-9 compared with healthy controls (LCN2: P

AB - Objectives: Recent evidence demonstrated that lipocalin (LCN)2 is induced in many types of human cancer, while the detection of its complex with matrix metalloproteinase (MMP)-9 is correlated with the cancer disease status. We attempted to evaluate plasma expressions of LCN2, MMP-9, and their complex (LCN2/MMP-9) during the diagnostic work-up of patients with oral squamous cell carcinoma (OSCC) and investigated their correlations with disease progression. Methods: In total, 195 patients with OSCC and 81 healthy controls were recruited. Expression levels of LCN2, MMP-9, and LCN2/MMP-9 were determined with immunoenzymatic assays. Results: Patients with OSCC exhibited significantly higher levels of LCN2, MMP-9, and LCN2/MMP-9 compared with healthy controls (LCN2: P

KW - Lipocalin 2

KW - Matrix metalloproteinase-9

KW - Oral squamous cell carcinoma

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SN - 1354-523X

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JO - Oral Diseases

JF - Oral Diseases

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ER -

Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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