@article{9394592f037c48b3bc673cc04f61479a,
title = "Robust deep brain stimulation functional MRI procedures in rats and mice using an MR-compatible tungsten microwire electrode",
abstract = "Purpose: To develop a series of robust and readily adoptable protocols for the application of deep brain stimulation (DBS)-functional MRI (fMRI) in rodents. Methods: DBS-fMRI procedures were conducted in rat and mouse under varying anesthetic conditions (isoflurane in rat and mouse, α-chloralose in rat). A homemade two-channel tungsten microwire electrode was used to minimize magnetic susceptibility artifacts, and was targeted to the ventral poster-omedial (VPM) thalamus for DBS-fMRI scanning procedures. Results: Compared with a commercially available MR-compatible electrode, the tungsten microwire generated greatly reduced magnetic-susceptibility artifacts. In the rat, VPM-DBS using the microwire electrode resulted in robust positive blood-oxygen- level-dependent signal changes in somatosensory cortex that were relatively independent of anesthetic type. In the mouse, VPM-DBS similarly generated large, positive neurovascular responses in somatosensory cortex that were detected using cerebral blood volume measurements. Conclusion: Collectively, this work describes reasonable and easily adoptable procedures for conducting DBS-fMRI studies in rodent models. The protocols developed herein may be extended to study DBS effects under numerous experimental conditions and at varying stimulation targets. {\textcopyright} 2014 Wiley Periodicals, Inc.",
keywords = "Deep brain stimulation, fMRI, Mouse, Rat, Tungsten electrode, chloralose, isoflurane, tungsten, biomaterial, Article, BOLD signal, brain blood volume, brain depth stimulation, controlled study, electrostimulation, functional magnetic resonance imaging, male, microelectrode, mouse, neuroscience, nonhuman, rat, somatosensory cortex, thalamus nucleus, anatomy and histology, animal, brain, device failure analysis, devices, equipment design, evoked response, nuclear magnetic resonance imaging, physiology, reproducibility, sensitivity and specificity, Sprague Dawley rat, synthesis, Animals, Biocompatible Materials, Brain, Deep Brain Stimulation, Equipment Design, Equipment Failure Analysis, Evoked Potentials, Magnetic Resonance Imaging, Male, Microelectrodes, Rats, Rats, Sprague-Dawley, Reproducibility of Results, Sensitivity and Specificity, Tungsten",
author = "Hsin-Yi Lai and Albaugh, {Daniel L.} and Kao, {Yu-Chieh Jill} and Younce, {John Robert} and Yen-Yu Shih",
note = "被引用次數：2 Export Date: 6 April 2016 CODEN: MRMEE 通訊地址: Shih, Y.-Y.I.; Department of Neurology, Biomedical Research Imaging Center, University of North Carolina, 130 Mason Farm Road, CB 7513, United States 化學物質/CAS: chloralose, 15879-93-3; isoflurane, 26675-46-7; tungsten, 7440-33-7; Biocompatible Materials; Tungsten 參考文獻: Delong, M., Wichmann, T., Deep brain stimulation for movement and other neurologic disorders (2012) Ann N y Acad Sci, 1265, pp. 1-8; Goodman, W.K., Alterman, R.L., Deep brain stimulation for intractable psychiatric disorders (2012) Annu Rev Med, 63, pp. 511-524; Schiefer, T.K., Matsumoto, J.Y., Lee, K.H., Moving forward: Advances in the treatment of movement disorders with deep brain stimulation (2011) Front Integr Neurosci, 5, p. 69; Gradinaru, V., Mogri, M., Thompson, K.R., Henderson, J.M., Deisseroth, K., Optical deconstruction of parkinsonian neural circuitry (2009) Science, 324, pp. 354-359; Li, Q., Ke, Y., Chan, D.C., Qian, Z.M., Yung, K.K., Ko, H., Arbuthnott, G.W., Yung, W.H., Therapeutic deep brain stimulation in Parkinsonian rats directly influences motor cortex (2012) Neuron, 76, pp. 1030-1041; McConnell, G.C., So, R.Q., Hilliard, J.D., Lopomo, P., Grill, W.M., Effective deep brain stimulation suppresses low-frequency network oscillations in the basal ganglia by regularizing neural firing patterns (2012) J Neurosci, 32, pp. 15657-15668; Liu, Y., Postupna, N., Falkenberg, J., Anderson, M.E., High frequency deep brain stimulation: What are the therapeutic mechanisms? (2008) Neurosci Biobehav Rev, 32, pp. 343-351; Albaugh, D.L., Shih, Y.Y., Neural circuit modulation during deep brain stimulation at the subthalamic nucleus for Parkinson's disease: What have we learned from neuroimaging studies? (2014) Brain Connect, 4, pp. 1-14; Yang, P., Chen, Y., Chen, D., Hu, J., Chen, J., Yen, C., Comparison of fMRI BOLD response patterns by electrical stimulation of the ventroposterior complex and medial thalamus of the rat (2013) PloS One, 8, p. e66821; Lai, H.Y., Liao, L.D., Lin, C.T., Hsu, J.H., He, X., Chen, Y.Y., Chang, J.Y., Shih, Y.Y., Design, simulation and experimental validation of a novel flexible neural probe for deep brain stimulation and multichannel recording (2012) J Neural Eng, 9, p. 036001; Shih, Y.Y., Yash, T.V., Rogers, B., Duong TQ. fMRI of deep brain stimulation at the rat ventral posteromedial thalamus (2014) Brain Stimul, 7, pp. 190-193; Adamczak, J.M., Farr, T.D., Seehafer, J.U., Kalthoff, D., Hoehn, M., High field BOLD response to forepaw stimulation in the mouse (2010) Neuroimage, 51, pp. 704-712; Bosshard, S.C., Baltes, C., Wyss, M.T., Mueggler, T., Weber, B., Rudin, M., Assessment of brain responses to innocuous and noxious electrical forepaw stimulation in mice using BOLD fMRI (2010) Pain, 151, pp. 655-663; Ahrens, E.T., Dubowitz, D.J., Peripheral somatosensory fMRI in mouse at 11.7 T (2001) NMR Biomed, 14, pp. 318-324; Nair, G., Duong, T.Q., Echo-planar BOLD fMRI of mice on a narrow-bore 9.4 T magnet (2004) Magn Reson Med, 52, pp. 430-434; Paxinos, G., Watson, C., (2004) The Rat Brain in Stereotaxic Coordinates: 5th Edition, , New York: Academic Press; Shih, Y.Y., Chen, Y.Y., Lai, H.Y., Kao, Y.C., Shyu, B.C., Duong, T.Q., Ultra high-resolution fMRI and electrophysiology of the rat primary somatosensory cortex (2013) Neuroimage, 73, pp. 113-120; Prasad, A., Xue, Q.S., Sankar, V., Nishida, T., Shaw, G., Streit, W.J., Sanchez, J.C., Comprehensive characterization and failure modes of tungsten microwire arrays in chronic neural implants (2012) J Neural Eng, 9, p. 056015; Patrick, E., Orazem, M.E., Sanchez, J.C., Nishida, T., Corrosion of tungsten microelectrodes used in neural recording applications (2011) J Neurosci Methods, 198, pp. 158-171; Zeuthen, T., Tungsten (W) as electrode material: Electrode potential and small-signal impedances (1978) Med Biol Eng Comput, 16, pp. 483-488; Williams, K.A., Magnuson, M., Majeed, W., Laconte, S.M., Peltier, S.J., Hu, X., Keilholz, S.D., Comparison of alpha-chloralose, medetomidine and isoflurane anesthesia for functional connectivity mapping in the rat (2010) Magn Reson Imaging, 28, pp. 995-1003; Krautwald, K., Angenstein, F., Low frequency stimulation of the perforant pathway generates anesthesia-specific variations in neural activity and BOLD responses in the rat dentate gyrus (2012) J Cereb Blood Flow Metab, 32, pp. 291-305; Tsurugizawa, T., Uematsu, A., Uneyama, H., Torii, K., Effects of isoflurane and alpha-chloralose anesthesia on BOLD fMRI responses to ingested L-glutamate in rats (2010) Neuroscience, 165, pp. 244-251; Alonso Bde, C., Makarova, T., Hess, A., On the use of alpha-chloralose for repeated BOLD fMRI measurements in rats (2011) J Neurosci Methods, 195, pp. 236-240; Sommers, M.G., Van Egmond, J., Booij, L.H., Heerschap, A., Isoflurane anesthesia is a valuable alternative for alpha-chloralose anesthesia in the forepaw stimulation model in rats (2009) NMR Biomed, 22, pp. 414-418; Masamoto, K., Kim, T., Fukuda, M., Wang, P., Kim, S.G., Relationship between neural, vascular, and BOLD signals in isoflurane-anesthetized rat somatosensory cortex (2007) Cereb Cortex, 17, pp. 942-950; Keilholz, S.D., Silva, A.C., Raman, M., Merkle, H., Koretsky, A.P., BOLD and CBV-weighted functional magnetic resonance imaging of the rat somatosensory system (2006) Magn Reson Med, 55, pp. 316-324; Kim, T., Masamoto, K., Fukuda, M., Vazquez, A., Kim, S.G., Frequency-dependent neural activity, CBF, and BOLD fMRI to somatosensory stimuli in isoflurane-anesthetized rats (2010) Neuroimage, 52, pp. 224-233; Sanganahalli, B.G., Herman, P., Hyder, F., Frequency-dependent tactile responses in rat brain measured by functional MRI (2008) NMR Biomed, 21, pp. 410-416; Canals, S., Beyerlein, M., Murayama, Y., Logothetis, N.K., Electric stimulation fMRI of the perforant pathway to the rat hippocampus (2008) Magn Reson Imaging, 26, pp. 978-986; Lai, H.-Y., Younce, J.R., Albaugh, D.L., Kao, Y.-C.J., Shih, Y.-Y.I., Functional MRI reveals frequency-dependent responses during deep brain stimulation at the subthalamic nucleus or internal globus pallidus (2014) Neuroimage, 84, pp. 11-18; Kim, S.G., Harel, N., Jin, T., Kim, T., Lee, P., Zhao, F., Cerebral blood volume MRI with intravascular superparamagnetic iron oxide nanoparticles (2013) NMR Biomed, 26, pp. 949-962; Lu, H., Chefer, S., Kurup, P.K., Guillem, K., Vaupel, D.B., Ross, T.J., Moore, A., Peoples, L.L., Stein EA. fMRI response in the medial prefrontal cortex predicts cocaine but not sucrose self-administration history (2012) Neuroimage, 62, pp. 1857-1866; Mueggler, T., Razoux, F., Russig, H., Buehler, A., Franklin, T.B., Baltes, C., Mansuy, I.M., Rudin, M., Mapping of CBV changes in 5-HT(1A) terminal fields by functional MRI in the mouse brain (2011) Eur Neuropsychopharmacol, 21, pp. 344-353; Perles-Barbacaru, T.A., Procissi, D., Demyanenko, A.V., Hall, F.S., Uhl, G.R., Jacobs, R.E., Quantitative pharmacologic MRI: Mapping the cerebral blood volume response to cocaine in dopamine transporter knockout mice (2011) Neuroimage, 55, pp. 622-628",
year = "2015",
doi = "10.1002/mrm.25239",
language = "English",
volume = "73",
pages = "1246--1251",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "3",
}