TY - JOUR
T1 - Risks of all-cause mortality and major kidney events in patients with new-onset primary open-angle glaucoma
T2 - A nationwide long-term cohort study in Taiwan
AU - Chou, Chu Lin
AU - Hsieh, Tsung Cheng
AU - Chen, Jin Shuen
AU - Fang, Te Chao
N1 - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Objective Cardiovascular risk factors are associated with primary open-angle glaucoma (POAG) in the general population. However, long-term mortality and major kidney events in patients with new-onset POAG remain unclear. Methods Using the Taiwan National Health Insurance Research Database between 1997 and 2011, 15 185 patients with a new diagnosis of POAG were enrolled and propensity score matched (1:1) with 15 185 patients without ocular disorders (WODs). All-cause mortality and major kidney events were analysed by a multivariate Cox proportional hazards regression model and a competing risk regression model. Results The risk of all-cause mortality was significantly higher in patients with new-onset POAG than in those WODs (adjusted HR (aHR) 2.11, 95% CI 1.76 to 2.54; p<0.001). Patients with POAG had higher risks of acute renal failure (ARF) (competing risk aHR 2.58, 95% CI 1.88 to 3.55; p<0.001) and end-stage renal disease (ESRD) (competing risk aHR 4.84, 95% CI 3.02 to 7.77; p<0.001) than those WODs. Conclusions Our data demonstrate that POAG is a risk of all-cause mortality, ARF and ESRD, thus needing to notice mortality and major kidney events in patients with new-onset POAG.
AB - Objective Cardiovascular risk factors are associated with primary open-angle glaucoma (POAG) in the general population. However, long-term mortality and major kidney events in patients with new-onset POAG remain unclear. Methods Using the Taiwan National Health Insurance Research Database between 1997 and 2011, 15 185 patients with a new diagnosis of POAG were enrolled and propensity score matched (1:1) with 15 185 patients without ocular disorders (WODs). All-cause mortality and major kidney events were analysed by a multivariate Cox proportional hazards regression model and a competing risk regression model. Results The risk of all-cause mortality was significantly higher in patients with new-onset POAG than in those WODs (adjusted HR (aHR) 2.11, 95% CI 1.76 to 2.54; p<0.001). Patients with POAG had higher risks of acute renal failure (ARF) (competing risk aHR 2.58, 95% CI 1.88 to 3.55; p<0.001) and end-stage renal disease (ESRD) (competing risk aHR 4.84, 95% CI 3.02 to 7.77; p<0.001) than those WODs. Conclusions Our data demonstrate that POAG is a risk of all-cause mortality, ARF and ESRD, thus needing to notice mortality and major kidney events in patients with new-onset POAG.
KW - acute renal failure
KW - end-stage renal disease
KW - mortality
KW - primary open-angle glaucoma
UR - http://www.scopus.com/inward/record.url?scp=85053072688&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053072688&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2017-021270
DO - 10.1136/bmjopen-2017-021270
M3 - Article
C2 - 29572399
AN - SCOPUS:85053072688
SN - 2044-6055
VL - 8
SP - e021270
JO - BMJ Open
JF - BMJ Open
IS - 3
M1 - e021270
ER -