Risk of sepsis in patients with primary aldosteronism 11 Medical and Health Sciences 1103 Clinical Sciences

Chieh Kai Chan, Ya Hui Hu, Likwang Chen, Chin Chen Chang, Yu Feng Lin, Tai Shuan Lai, Kuo How Huang, Yen Hung Lin, Vin Cent Wu, Kwan Dun Wu, Jui Hsiang Lin, Wei Jie Wang, Che Hsiung Wu, Chia Hui Chang, Ya Li Chang, Yao Chou Tsai, Chih Chin Yu, Hung Wei Chang, Lian Yu Lin, Fu Chang HuShuo Meng Wang, Shih Cheng Liao, Ching Chu Lu, Ruoh Fang Yen

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Background: The interaction between hyperaldosteronism and immune dysfunction has been reported and glucocorticoid co-secretion is frequently found in primary aldosteronism (PA). The aforementioned conditions raise the possibility of the infection risk; however, clinical episodes of sepsis have not been reported in PA. Methods: Using Taiwan's National Health Insurance Research Database between 1997 and 2009, we identified PA and aldosterone-producing adenoma (APA) matched with essential hypertension (EH) at a 1:1 ratio by propensity scores. The incidences of sepsis and mortality after the index date were evaluated, and the risk factors of outcomes were identified using adjusted Cox proportional hazards models and taking mortality as a competing risk. Results: We enrolled 2448 patients with PA (male, 46.08%; mean age, 48.4 years). There were 875 patients who could be ascertained as APA. Taking mortality as the competing risk, APA patients had a lower incidence of sepsis than their matched EH patients (hazard ratio (HR) 0.29; P < 0.001) after target treatments. Patients receiving adrenalectomy showed a benefit of decreasing the risk of sepsis (PA vs EH, HR 0.14, P = 0.001; APA vs EH, HR 0.16, P = 0.003), but mineralocorticoid receptor antagonist treatment may differ. Compared with matched control cohorts, patients with APA had a lower risk of all-cause mortality (PA, adjusted HR 0.84, P = 0.050; APA, adjusted HR 0.31, P < 0.001) after target treatments. Conclusions: Our study demonstrated that patients with PA/APA who underwent adrenalectomy could attenuate the risk of sepsis compared with their matched EH patients. We further found that APA patients with target treatments could decrease all-cause mortality compared with EH patients.

Original languageEnglish
Article number313
JournalCritical Care
Issue number1
Publication statusPublished - Nov 21 2018


  • Chronic inflammation
  • Glucocorticoid
  • Hypertension
  • Oxidative stress
  • Primary aldosteronism
  • Sepsis
  • Taiwan Primary Aldosteronism Investigation

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


Dive into the research topics of 'Risk of sepsis in patients with primary aldosteronism 11 Medical and Health Sciences 1103 Clinical Sciences'. Together they form a unique fingerprint.

Cite this