TY - JOUR
T1 - Risk of retinal diseases in patients with psoriasis
T2 - A population-based cohort study in Taiwan
AU - Dai, Ying Xiu
AU - Tai, Ying Hsuan
AU - Lee, Din Dar
AU - Chang, Yun Ting
AU - Chen, Tzeng Ji
AU - Chen, Mu Hong
N1 - Funding Information:
This study was funded by a grant from the Ministry of Science and Technology, Republic of China (MOST 107‐2314‐B‐075‐032‐MY3‐2).
Publisher Copyright:
© 2021 Japanese Dermatological Association
PY - 2021/10
Y1 - 2021/10
N2 - Psoriasis has been associated with the risk of several ocular complications; however, its relationship with retinal diseases remains unknown. This study aimed to investigate the risk of developing retinal diseases in patients with psoriasis. Study participants were recruited from the National Health Insurance Research Database in Taiwan. A total of 11 729 psoriasis patients and 117 290 matched controls were included, showing an incidence rate of 121.15 and 28.34 cases of retinal diseases per 100 000 person-years, respectively. Compared with controls, patients with psoriasis had an adjusted hazard ratio (aHR) of 3.40 (95% confidence interval [CI], 2.63–4.39) for retinal diseases after adjustment for potential confounders. Regarding the individual retinal disease, psoriasis patients had a significantly higher risk of developing retinal detachment (aHR, 5.07; 95% CI, 2.92–8.79), retinal vascular occlusion (aHR, 3.75; 95% CI 2.42–5.82), and retinopathy (aHR, 2.84; 95% CI, 1.99–4.05) than controls. In conclusion, patients with psoriasis had a significantly higher risk of retinal diseases than controls. Further studies are necessary to investigate the pathophysiology underlying the relationship between psoriasis and retinal diseases.
AB - Psoriasis has been associated with the risk of several ocular complications; however, its relationship with retinal diseases remains unknown. This study aimed to investigate the risk of developing retinal diseases in patients with psoriasis. Study participants were recruited from the National Health Insurance Research Database in Taiwan. A total of 11 729 psoriasis patients and 117 290 matched controls were included, showing an incidence rate of 121.15 and 28.34 cases of retinal diseases per 100 000 person-years, respectively. Compared with controls, patients with psoriasis had an adjusted hazard ratio (aHR) of 3.40 (95% confidence interval [CI], 2.63–4.39) for retinal diseases after adjustment for potential confounders. Regarding the individual retinal disease, psoriasis patients had a significantly higher risk of developing retinal detachment (aHR, 5.07; 95% CI, 2.92–8.79), retinal vascular occlusion (aHR, 3.75; 95% CI 2.42–5.82), and retinopathy (aHR, 2.84; 95% CI, 1.99–4.05) than controls. In conclusion, patients with psoriasis had a significantly higher risk of retinal diseases than controls. Further studies are necessary to investigate the pathophysiology underlying the relationship between psoriasis and retinal diseases.
KW - psoriasis
KW - retinal detachment
KW - retinal diseases
KW - retinal vascular occlusion
KW - retinopathy
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U2 - 10.1111/1346-8138.16062
DO - 10.1111/1346-8138.16062
M3 - Article
C2 - 34268803
AN - SCOPUS:85110183118
SN - 0385-2407
VL - 48
SP - 1550
EP - 1556
JO - Journal of Dermatology
JF - Journal of Dermatology
IS - 10
ER -