TY - JOUR
T1 - Risk of non-melanoma skin cancer in patients with chronic kidney disease and its relationship to uraemic pruritus
AU - Wang, Chia Chen
AU - Tang, Chao Hsiun
AU - Huang, Siao Yuan
AU - Huang, Kuan Chih
AU - Sue, Yuh Mou
N1 - Publisher Copyright:
© 2017 Acta Dermato-Venereologica.
PY - 2017/11
Y1 - 2017/11
N2 - This study investigated the risk of non-melanoma skin cancer (NMSC) in pre-dialysis patients with chronic kidney disease (CKD) and explored associated risk factors. A population-based cohort of 1,515,858 Taiwanese CKD patients was included. The standardized incidence ratio (SIR) for incident NMSC was determined. Compared with the general population, a 1.14- fold risk of NMSC was found in the CKD cohort. NMSC risk was significant in patients with pre-dialysis stage 5 CKD and anaemia (1.48-fold), and in those with uraemic pruritus after long-term antihistamine treatment (1.38-fold). A higher SIR for NMSC was found in younger patients with CKD (age < 70 years, 1.34-fold; age 20–39 years, 1.63-fold), stage 5 CKD with anaemia (age < 70 years, 2.09-fold), and uraemic pruritus (age <70 years, 2.22-fold). Pre-dialysis patients with CKD are at higher risk of NMSC, especially those with advanced-stage CKD, and those with uraemic pruritus.
AB - This study investigated the risk of non-melanoma skin cancer (NMSC) in pre-dialysis patients with chronic kidney disease (CKD) and explored associated risk factors. A population-based cohort of 1,515,858 Taiwanese CKD patients was included. The standardized incidence ratio (SIR) for incident NMSC was determined. Compared with the general population, a 1.14- fold risk of NMSC was found in the CKD cohort. NMSC risk was significant in patients with pre-dialysis stage 5 CKD and anaemia (1.48-fold), and in those with uraemic pruritus after long-term antihistamine treatment (1.38-fold). A higher SIR for NMSC was found in younger patients with CKD (age < 70 years, 1.34-fold; age 20–39 years, 1.63-fold), stage 5 CKD with anaemia (age < 70 years, 2.09-fold), and uraemic pruritus (age <70 years, 2.22-fold). Pre-dialysis patients with CKD are at higher risk of NMSC, especially those with advanced-stage CKD, and those with uraemic pruritus.
KW - Chronic kidney disease
KW - Epidemiology
KW - Non-melanoma skin cancer
KW - Uraemic pruritus
UR - http://www.scopus.com/inward/record.url?scp=85032655703&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85032655703&partnerID=8YFLogxK
U2 - 10.2340/00015555-2762
DO - 10.2340/00015555-2762
M3 - Article
AN - SCOPUS:85032655703
SN - 0001-5555
VL - 97
SP - 1230
EP - 1234
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
IS - 10
ER -
