Risk of Hepato-Biliary Cancer After Cholecystectomy: A Nationwide Cohort Study

Wei Yu Kao, Chian Yaw Hwang, Chien Wei Su, Yun Ting Chang, Jiing Chyuan Luo, Ming Chih Hou, Han Chieh Lin, Fa Yauh Lee, Jaw Ching Wu

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Background: Epidemiologic studies have identified cholecystectomy as a possible risk factor for cancers in Western countries. The aim of this study was to estimate the risk of hepato-biliary cancer after cholecystectomy in Taiwan. Methods: Based on the Taiwan National Health Insurance Research Database, 2,590 cholecystectomized patients without prior cancers in the period 1996-2008 were identified from a cohort dataset of 1,000,000 randomly sampled individuals. The standard incidence ratio (SIR) of each cancer was calculated. Results: After a median follow-up of 4.82 years, 67 liver cancer and 17 biliary tract cancer patients were diagnosed. Patients who received cholecystectomy had higher risks of liver cancer (SIR, 3.29) and biliary tract cancer (SIR, 8.50). Cholecystectomized patients aged ≤60 years had higher risks of liver cancer (SIR, 11.14) and biliary tract cancer (SIR, 55.86) compared to those aged >60 years (SIR, 2.31 and 5.67). Female cholecystectomized patients had higher risks of liver cancer (SIR, 4.18) and biliary tract cancer (SIR, 10.56) than males (SIR, 2.96 and 7.26). Cholecystectomized patients with cirrhosis had higher SIR of liver cancer than patients without cirrhosis (SIR, 33.84 vs. 1.41). Conclusions: Cholecystectomy may be associated with an increased risk of hepato-biliary cancer. Further and regular surveillance should be performed on such patients.

Original languageEnglish
Pages (from-to)345-351
Number of pages7
JournalJournal of Gastrointestinal Surgery
Issue number2
Publication statusPublished - Jan 1 2013
Externally publishedYes


  • Cancer risk
  • Cholecystectomy
  • Epidemiology

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology


Dive into the research topics of 'Risk of Hepato-Biliary Cancer After Cholecystectomy: A Nationwide Cohort Study'. Together they form a unique fingerprint.

Cite this