Risk of central serous chorioretinopathy in adults prescribed oral corticosteroids: A population-based study in Taiwan

Der Chong Tsai, Shih Jen Chen, Chin Chou Huang, Pesus Chou, Chia Min Chung, Wan Leong Chan, Po Hsun Huang, Shing Jong Lin, Jaw Wen Chen, Tseng Ji Chen, Hsin Bang Leu

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

PURPOSE:: To investigate the incidence and risk factors for central serous chorioretinopathy (CSCR) in adults who use oral corticosteroids in Taiwan. METHODS:: This is a population-based nested case-control study between 2000 and 2008. From the Taiwan National Health Insurance Research Database, adults who were repetitively prescribed oral corticosteroids were included as the study cohort. Of those, newly diagnosed CSCR cases were identified and the CSCR incidence was calculated. Subjects matched for age, gender, and the enrollment time were randomly selected as the controls. Corticosteroids use was compared between the cases and controls. Poisson and conditional logistic regressions were used to analyze the potential risk factors for CSCR. RESULTS:: Among 142,035 oral corticosteroids users, 320 cases of CSCR were identified, and 1,554 matched controls were randomly selected. The incidence rate of CSCR was 44.4 (95% confidence interval, 39.5-49.3) cases per 100,000 person-years. Multivariate Poisson regression showed that male patients and those aged 35 years to 44 years had significantly higher incidence rates of CSCR. There were no differences in either median dosage or mean duration of systemic corticosteroid treatment between the cases and controls. After adjusting for other confounders, current use of oral corticosteroids was found to be significantly associated with the risk of CSCR (odds ratio, 2.40; 95% confidence interval, 1.49-3.89). CONCLUSION:: Male gender, middle age, and current use of oral corticosteroids were found to be the risk factors for CSCR. However, oral corticosteroids dosage and treatment duration were not associated with the CSCR risk.

Original languageEnglish
Pages (from-to)1867-1874
Number of pages8
JournalRetina
Volume34
Issue number9
DOIs
Publication statusPublished - Sept 2014
Externally publishedYes

Keywords

  • Central serous chorioretinopathy
  • Corticosteroids
  • National Health Insurance Research Database
  • Population-based study

ASJC Scopus subject areas

  • Ophthalmology

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