TY - JOUR
T1 - Risk of Autism Associated With General Anesthesia During Cesarean Delivery
T2 - A Population-Based Birth-Cohort Analysis
AU - Chien, Li Nien
AU - Lin, Hsiu Chen
AU - Shao, Yu Hsuan Joni
AU - Chiou, Shu Ti
AU - Chiou, Hung Yi
N1 - Publisher Copyright:
© 2014, Springer Science+Business Media New York.
PY - 2015/3/20
Y1 - 2015/3/20
N2 - The rates of Cesarean delivery (C-section) have risen to >30 % in numerous countries. Increased risk of autism has been shown in neonates delivered by C-section. This study examined the incidence of autism in neonates delivered vaginally, by C-section with regional anesthesia (RA), and by C-section with general anesthesia (GA) to evaluate the risk of autism associated with C-section and obstetric anesthesia. During a mean follow-up of 4.3 years, the incidence of autism was higher in neonates delivered by C-section with GA than in neonates delivered vaginally, with an adjusted risk of 1.52 (95 % confidence interval 1.18–1.94). However, the adjusted risk of autism in neonates delivered by C-section with RA and in neonates delivered vaginally was nonsignificantly different.
AB - The rates of Cesarean delivery (C-section) have risen to >30 % in numerous countries. Increased risk of autism has been shown in neonates delivered by C-section. This study examined the incidence of autism in neonates delivered vaginally, by C-section with regional anesthesia (RA), and by C-section with general anesthesia (GA) to evaluate the risk of autism associated with C-section and obstetric anesthesia. During a mean follow-up of 4.3 years, the incidence of autism was higher in neonates delivered by C-section with GA than in neonates delivered vaginally, with an adjusted risk of 1.52 (95 % confidence interval 1.18–1.94). However, the adjusted risk of autism in neonates delivered by C-section with RA and in neonates delivered vaginally was nonsignificantly different.
KW - Autism
KW - Cesarean delivery
KW - Obstetric anesthesia
KW - Population-based birth cohort
UR - https://www.scopus.com/pages/publications/84925492013
UR - https://www.scopus.com/inward/citedby.url?scp=84925492013&partnerID=8YFLogxK
U2 - 10.1007/s10803-014-2247-y
DO - 10.1007/s10803-014-2247-y
M3 - Article
C2 - 25256350
AN - SCOPUS:84925492013
SN - 0162-3257
VL - 45
SP - 932
EP - 942
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 4
ER -