Risk factors for recurrent hypoglycemia in hospitalized diabetic patients admitted for severe hypoglycemia

Yen Yue Lin, Chin Wang Hsu, Wayne Huey Herng Sheu, Shi Jye Chu, Chin Pyng Wu, Shih Hung Tsai

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)


Purpose: Severe hypoglycemia can result in neural damage, impaired cognitive function, coma, seizures, or death. The decision to admit diabetic patients after initial treatment in the emergency department remains unclear. Our purpose is to identify risk factors for developing recurrent hypoglycemia in diabetic patients admitted for severe hypoglycemia. Materials and Methods: We reviewed the records of 233 subjects (92 males, 141 females; mean age, 74.1 ± 9.8 years) with type 2 diabetes treated at a tertiary care teaching hospital and hospitalized for severe hypoglycemia. Results: Seventy-four (31.8%) patients were categorized with recurrent hypoglycemia and 159 (68.2%) with non-recurrent. Multivariate logistic regression analysis revealed that patients with loss of a recent meal, coronary artery disease, infection, and poor renal function (lower estimated glomerular filtration rate) were at risk for recurrent hypoglycemia. The use of calcium-channel blockers appeared to be a protective factor for the development of recurrent hypoglycemia. Conclusion: There may be a subset of patients with severe hypoglycemia and certain risk factors for recurrent hypoglycemia that should be admitted.

Original languageEnglish
Pages (from-to)367-374
Number of pages8
JournalYonsei Medical Journal
Issue number3
Publication statusPublished - May 2010


  • Calcium channel blockers
  • Chronic kidney disease
  • Coronary artery disease
  • Diabetic complications
  • Hypoglycemia
  • Mellitus
  • Type 2 diabetes

ASJC Scopus subject areas

  • Medicine(all)


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