TY - JOUR
T1 - Risk and prognostic significance of tuberculosis in patients from The TREAT Asia HIV Observational Database
AU - Zhou, Jialun
AU - Elliott, Julian
AU - Li, Patrick C.K.
AU - Lim, Poh Lian
AU - Kiertiburanakul, Sasisopin
AU - Kumarasamy, Nagalingeswaran
AU - Merati, Tuti Parwati
AU - Pujari, Sanjay
AU - Chen, Yi Ming A.
AU - Phanuphak, Praphan
AU - Vonthanak, Saphonn
AU - Sirisanthana, Thira
AU - Sungkanuparph, Somnuek
AU - Lee, Christopher K.C.
AU - Kamarulzaman, Adeeba
AU - Oka, Shinichi
AU - Zhang, Fujie
AU - Tau, Goa
AU - Ditangco, Rossana
PY - 2009/4/21
Y1 - 2009/4/21
N2 - Background: To assess the risk and the prognostic significance of tuberculosis (TB) diagnosis in patients from The TREAT Asia HIV Observational Database, a multi-centre prospective cohort of HIV-infected patients receiving HIV care in the Asia-Pacific region. Methods: The risk of TB diagnosis after recruitment was assessed in patients with prospective follow-up. TB diagnosis was fitted as a time-dependent variable in assessing overall survival. Results: At baseline, 22% of patients were diagnosed with TB. TB incidence was 1.98 per 100 person-years during follow up, with predictors including younger age, lower recent CD4 count, duration of antiretroviral treatment, and living in high TB burden countries. Among 3279 patients during 6968 person-years, 142 died (2.04 per 100 person-years). Compared to patients with CDC category A or B illness only, mortality was marginally higher in patients with single Non-TB AIDS defining illness (ADI), or TB only (adjusted HR 1.35, p = 0.173) and highest in patients with multiple non-TB AIDS or both TB and other ADI (adjusted HR 2.21, p < 0.001). Conclusion: The risk of TB diagnosis was associated with increasing immunodeficiency and partly reduced by antiretroviral treatment. The prognosis of developing TB appeared to be similar to that following a diagnosis of other non-TB ADI.
AB - Background: To assess the risk and the prognostic significance of tuberculosis (TB) diagnosis in patients from The TREAT Asia HIV Observational Database, a multi-centre prospective cohort of HIV-infected patients receiving HIV care in the Asia-Pacific region. Methods: The risk of TB diagnosis after recruitment was assessed in patients with prospective follow-up. TB diagnosis was fitted as a time-dependent variable in assessing overall survival. Results: At baseline, 22% of patients were diagnosed with TB. TB incidence was 1.98 per 100 person-years during follow up, with predictors including younger age, lower recent CD4 count, duration of antiretroviral treatment, and living in high TB burden countries. Among 3279 patients during 6968 person-years, 142 died (2.04 per 100 person-years). Compared to patients with CDC category A or B illness only, mortality was marginally higher in patients with single Non-TB AIDS defining illness (ADI), or TB only (adjusted HR 1.35, p = 0.173) and highest in patients with multiple non-TB AIDS or both TB and other ADI (adjusted HR 2.21, p < 0.001). Conclusion: The risk of TB diagnosis was associated with increasing immunodeficiency and partly reduced by antiretroviral treatment. The prognosis of developing TB appeared to be similar to that following a diagnosis of other non-TB ADI.
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U2 - 10.1186/1471-2334-9-46
DO - 10.1186/1471-2334-9-46
M3 - Article
C2 - 19383122
AN - SCOPUS:65649133108
SN - 1471-2334
VL - 9
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
M1 - 46
ER -
