Abstract
The synthesis and complete characterization of all the monomers namely norbornene derived folate (mono 1), norbornene derived doxorubicin hydrazone linker (mono 2) and Norbornene derived barbiturate (NDB) are clearly described. The mono1 and mono2 are processed with diblock copolymerization whereas the homopolymerization of NDB is done through ring-opening metathesis polymerization (ROMP). In the covalent approach folic acid (FA) is used as the receptor-targeted anti-cancer therapy. The primary purpose of using drug delivery systems with hydrogen linkages is attributed to its pH-responsive feature. So its quite evident when the drug release from micelles of FOL-DOX is significantly accelerated even at mildly acid pH of 5.5 to 6.0 compared to physiological pH of 7.4. In case of non covalent approach, the NDBH polymersomes are used as a nano carrier for anti cancer (DOX) drug delivery.
| Original language | English |
|---|---|
| Title of host publication | Computational and Experimental Chemistry |
| Subtitle of host publication | Developments and Applications |
| Publisher | Apple Academic Press |
| Pages | 193-227 |
| Number of pages | 35 |
| ISBN (Electronic) | 9781466568778 |
| ISBN (Print) | 9781926895291 |
| Publication status | Published - Jan 1 2013 |
Keywords
- Block copolymer
- Doxorubicin
- Grubbs’ catalyst
- Homopolymer
- Polyethylene glycol
- Schlenk flask
ASJC Scopus subject areas
- General Chemistry
- General Chemical Engineering
- General Physics and Astronomy
