Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 3232-3246 |
| Number of pages | 15 |
| Journal | Molecular and Cellular Biology |
| Volume | 25 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2005 |
Keywords
- cis acting element
- heterogeneous nuclear ribonucleoprotein
- heterogeneous nuclear ribonucleoprotein L
- heterogeneous nuclear ribonucleoprotein Q
- heterogeneous nuclear ribonucleoprotein R
- messenger RNA
- serotonin n acetyltransferase
- unclassified drug
- 3' untranslated region
- animal cell
- animal experiment
- animal tissue
- article
- circadian rhythm
- controlled study
- gene overexpression
- mathematical model
- nonhuman
- nucleotide sequence
- oscillation
- pineal body
- pinealocyte
- priority journal
- protein analysis
- rat
- RNA degradation
- RNA interference
- RNA stability
- species difference
- 3' Untranslated Regions
- Animals
- Arylalkylamine N-Acetyltransferase
- Base Sequence
- Circadian Rhythm
- Heterogeneous-Nuclear Ribonucleoproteins
- Molecular Sequence Data
- Pineal Gland
- Rats
- RNA Stability
- RNA, Messenger
- RNA, Small Interfering
- RNA-Binding Proteins
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In: Molecular and Cellular Biology, Vol. 25, No. 8, 2005, p. 3232-3246.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Rhythmic serotonin N-acetyltransferase mRNA degradation is essential for the maintenance of its circadian oscillation
AU - Kim, T.-D.
AU - Kim, J.-S.
AU - Jong, H.K.
AU - Myung, J.
AU - Chae, H.-D.
AU - Woo, K.-C.
AU - Sung, K.J.
AU - Koh, D.-S.
AU - Kim, K.-T.
N1 - 引用次數:56 Export Date: 18 September 2018 CODEN: MCEBD 通訊地址: Kim, K.-T.; National Research Laboratory, Department of Life Science, Pohang Univ. of Sci. and Technology, San 31 Hyoja-Dong, Pohang, Kyung-Buk 790-784, South Korea; 電子郵件: [email protected] 分析序列編號: GENBANK: AF004108, AF092100, AKK59705, AY184814, NM_001533, NM_005817, NM_017008, NM_177509, U29663, U38306, U46502, U46661, XM_008139; 化學物質/CAS: 3' Untranslated Regions; Arylalkylamine N-Acetyltransferase, EC 2.3.1.87; Heterogeneous-Nuclear Ribonucleoproteins; RNA, Messenger; RNA, Small Interfering; RNA-Binding Proteins 參考文獻: Andreason, G.L., Evans, G.A., Introduction and expression of DNA molecules in eukaryotic cells by electroporation (1988) BioTechniques, 6, pp. 650-660; Baler, R., Covington, S., Klein, D.C., The rat arylalkylamine N-acetyltransferase gene promoter: cAMP activation via a cAMP-responsive element-CCAAT complex (1997) J. Biol. 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PY - 2005
Y1 - 2005
N2 - Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase [AANAT]) is the key enzyme in melatonin synthesis regulated by circadian rhythm. To date, our understanding of the oscillatory mechanism of melatonin has been limited to autoregulatory transcriptional and posttranslational regulations of AANAT mRNA. In this study, we identify three proteins from pineal glands that associate with cis-acting elements within species-specific AANAT 3′ untranslated regions to mediate mRNA degradation. These proteins include heterogeneous nuclear ribonucleoprotein R (hnRNP R), hnRNP Q, and hnRNP L. Their RNA-destabilizing function was determined by RNA interference and overexpression approaches. Expression patterns of these factors in pineal glands display robust circadian rhythm. The enhanced levels detected after midnight correlate with an abrupt decline in AANAT mRNA level. A mathematical model for the AANAT mRNA profile and its experimental evidence with rat pinealocytes indicates that rhythmic AANAT mRNA degradation mediated by hnRNP R, hnRNP Q, and hnRNP L is a key process in the regulation of its circadian oscillation. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
AB - Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase [AANAT]) is the key enzyme in melatonin synthesis regulated by circadian rhythm. To date, our understanding of the oscillatory mechanism of melatonin has been limited to autoregulatory transcriptional and posttranslational regulations of AANAT mRNA. In this study, we identify three proteins from pineal glands that associate with cis-acting elements within species-specific AANAT 3′ untranslated regions to mediate mRNA degradation. These proteins include heterogeneous nuclear ribonucleoprotein R (hnRNP R), hnRNP Q, and hnRNP L. Their RNA-destabilizing function was determined by RNA interference and overexpression approaches. Expression patterns of these factors in pineal glands display robust circadian rhythm. The enhanced levels detected after midnight correlate with an abrupt decline in AANAT mRNA level. A mathematical model for the AANAT mRNA profile and its experimental evidence with rat pinealocytes indicates that rhythmic AANAT mRNA degradation mediated by hnRNP R, hnRNP Q, and hnRNP L is a key process in the regulation of its circadian oscillation. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
KW - cis acting element
KW - heterogeneous nuclear ribonucleoprotein
KW - heterogeneous nuclear ribonucleoprotein L
KW - heterogeneous nuclear ribonucleoprotein Q
KW - heterogeneous nuclear ribonucleoprotein R
KW - messenger RNA
KW - serotonin n acetyltransferase
KW - unclassified drug
KW - 3' untranslated region
KW - animal cell
KW - animal experiment
KW - animal tissue
KW - article
KW - circadian rhythm
KW - controlled study
KW - gene overexpression
KW - mathematical model
KW - nonhuman
KW - nucleotide sequence
KW - oscillation
KW - pineal body
KW - pinealocyte
KW - priority journal
KW - protein analysis
KW - rat
KW - RNA degradation
KW - RNA interference
KW - RNA stability
KW - species difference
KW - 3' Untranslated Regions
KW - Animals
KW - Arylalkylamine N-Acetyltransferase
KW - Base Sequence
KW - Circadian Rhythm
KW - Heterogeneous-Nuclear Ribonucleoproteins
KW - Molecular Sequence Data
KW - Pineal Gland
KW - Rats
KW - RNA Stability
KW - RNA, Messenger
KW - RNA, Small Interfering
KW - RNA-Binding Proteins
U2 - 10.1128/MCB.25.8.3232-3246.2005
DO - 10.1128/MCB.25.8.3232-3246.2005
M3 - Article
SN - 0270-7306
VL - 25
SP - 3232
EP - 3246
JO - Molecular and Cellular Biology
JF - Molecular and Cellular Biology
IS - 8
ER -