Resveratrol protects against methylglyoxal-induced hyperglycemia and pancreatic damage in vivo

An Sheng Cheng, Yu Hsiang Cheng, Chi Ying Lee, Chin Yuan Chung, Wen Chang Chang

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


Methylglyoxal (MG) has been found to cause inflammation and insulin resistance in vitro and in vivo in recent studies. Resveratrol has been proposed as an effective treatment that helps lower the risk of developing complications of diabetes. To study the significance of glycosylation-related stress on the pathology of diabetes, the effects of resveratrol were examined in a mouse model of diabetes induced by MG. Resveratrol was given via oral gavage in MG-treated mice, and diabetes-related tests and markers were assessed using biochemical and immunohistochemical analyses. Treatment with resveratrol markedly improved blood glucose level from the oral glucose tolerance test and promoted nuclear factor erythroid 2-related factor-2 (Nrf2) phosphorylation (p < 0.05) in the pancreas of MG-treated mice. However, these effects were abolished by retinoic acid, Nrf2 inhibitor, in resveratrol and retinoic acid-treated and MG-induced mice. These findings support that resveratrol may be useful in the treatment of type-2 diabetes by protecting against pancreatic cell dysfunction.

Original languageEnglish
Pages (from-to)2850-2865
Number of pages16
Issue number4
Publication statusPublished - Apr 15 2015
Externally publishedYes


  • Diabetes
  • Methylglyoxal
  • Nuclear factor erythroid 2-related factor 2
  • Resveratrol
  • Retinoic acid

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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