Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells

Ya Chen Ko; Chia Ling Chang; Hsiung-Fei Chien; Ching-Hsiang Wu; Liang In Lin

doi:10.1016/j.canlet.2011.05.014

Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells

Ya Chen Ko, Chia Ling Chang, Hsiung-Fei Chien, Ching-Hsiang Wu, Liang In Lin

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other plants, plays a protective role in human atherosclerosis and carcinogenesis. We examined the effects of resveratrol on the anaplastic large-cell lymphoma (ALCL) cell line SR-786. Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL.

Original language	English
Pages (from-to)	46-53
Number of pages	8
Journal	Cancer Letters
Volume	309
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2011.05.014
Publication status	Published - Oct 1 2011
Externally published	Yes

Keywords

Anaplastic large-cell lymphoma
Apoptosis
Differentiation
Fas/CD95
Resveratrol
SR-786

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2011.05.014

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title = "Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells",

abstract = "Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other plants, plays a protective role in human atherosclerosis and carcinogenesis. We examined the effects of resveratrol on the anaplastic large-cell lymphoma (ALCL) cell line SR-786. Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL.",

keywords = "Anaplastic large-cell lymphoma, Apoptosis, Differentiation, Fas/CD95, Resveratrol, SR-786",

author = "Ko, {Ya Chen} and Chang, {Chia Ling} and Hsiung-Fei Chien and Ching-Hsiang Wu and Lin, {Liang In}",

note = "Funding Information: This work was supported by research grants from the National Science Council (NSC 98-2622-8-002-006-A2 and 98-2120-M-002-009), Taiwan.",

year = "2011",

month = oct,

day = "1",

doi = "10.1016/j.canlet.2011.05.014",

language = "English",

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journal = "Cancer Letters",

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T1 - Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells

AU - Ko, Ya Chen

AU - Chang, Chia Ling

AU - Chien, Hsiung-Fei

AU - Wu, Ching-Hsiang

AU - Lin, Liang In

N1 - Funding Information: This work was supported by research grants from the National Science Council (NSC 98-2622-8-002-006-A2 and 98-2120-M-002-009), Taiwan.

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other plants, plays a protective role in human atherosclerosis and carcinogenesis. We examined the effects of resveratrol on the anaplastic large-cell lymphoma (ALCL) cell line SR-786. Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL.

AB - Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other plants, plays a protective role in human atherosclerosis and carcinogenesis. We examined the effects of resveratrol on the anaplastic large-cell lymphoma (ALCL) cell line SR-786. Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL.

KW - Anaplastic large-cell lymphoma

KW - Apoptosis

KW - Differentiation

KW - Fas/CD95

KW - Resveratrol

KW - SR-786

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SN - 0304-3835

VL - 309

SP - 46

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JO - Cancer Letters

JF - Cancer Letters

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Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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