Resistin mRNA levels are downregulated by estrogen in vivo and in vitro

Seng Wong Huang; Kok Min Seow; Low Tone Ho; Yueh Chien; Dong Yue Chung; Chih Ling Chang; Ying Hsiu Lai; Jiann Loung Hwang; Chi Chang Juan

doi:10.1016/j.febslet.2004.12.010

Resistin mRNA levels are downregulated by estrogen in vivo and in vitro

Seng Wong Huang, Kok Min Seow, Low Tone Ho, Yueh Chien, Dong Yue Chung, Chih Ling Chang, Ying Hsiu Lai, Jiann Loung Hwang, Chi Chang Juan

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Resistin, a hormone secreted by adipocytes, is suggested to be an important link between obesity and diabetes. The aim of this study was to evaluate the regulatory effect of estrogen on adipocyte resistin gene expression in ovariectomized (OVX) rats and in isolated rat adipocytes in vitro. Subcutaneous injection of estradiol benzoate reduced resistin mRNA levels in adipocytes isolated from the inguinal, parametrial, perirenal, retroperitoneal, or periovarian fat deposits of OVX rats, while an in vitro study showed that estradiol treatment decreased resistin mRNA levels in cultured rat periovarian fat adipocytes. Results of Western blotting analysis also showed that estrogen decreased adipose resistin contents in vivo and in vitro. These data suggest that estrogen is a pivotal negative regulator of resistin gene expression.

Original language	English
Pages (from-to)	449-454
Number of pages	6
Journal	FEBS Letters
Volume	579
Issue number	2
DOIs	https://doi.org/10.1016/j.febslet.2004.12.010
Publication status	Published - Jan 17 2005

Keywords

Adipocyte
Estrogen
Ovariectomy
Resistin

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.febslet.2004.12.010

Cite this

@article{e0be37f2ef5144e99cc106e06d3fdf67,

title = "Resistin mRNA levels are downregulated by estrogen in vivo and in vitro",

abstract = "Resistin, a hormone secreted by adipocytes, is suggested to be an important link between obesity and diabetes. The aim of this study was to evaluate the regulatory effect of estrogen on adipocyte resistin gene expression in ovariectomized (OVX) rats and in isolated rat adipocytes in vitro. Subcutaneous injection of estradiol benzoate reduced resistin mRNA levels in adipocytes isolated from the inguinal, parametrial, perirenal, retroperitoneal, or periovarian fat deposits of OVX rats, while an in vitro study showed that estradiol treatment decreased resistin mRNA levels in cultured rat periovarian fat adipocytes. Results of Western blotting analysis also showed that estrogen decreased adipose resistin contents in vivo and in vitro. These data suggest that estrogen is a pivotal negative regulator of resistin gene expression.",

keywords = "Adipocyte, Estrogen, Ovariectomy, Resistin",

author = "Huang, {Seng Wong} and Seow, {Kok Min} and Ho, {Low Tone} and Yueh Chien and Chung, {Dong Yue} and Chang, {Chih Ling} and Lai, {Ying Hsiu} and Hwang, {Jiann Loung} and Juan, {Chi Chang}",

year = "2005",

month = jan,

day = "17",

doi = "10.1016/j.febslet.2004.12.010",

language = "English",

volume = "579",

pages = "449--454",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Resistin mRNA levels are downregulated by estrogen in vivo and in vitro

AU - Huang, Seng Wong

AU - Seow, Kok Min

AU - Ho, Low Tone

AU - Chien, Yueh

AU - Chung, Dong Yue

AU - Chang, Chih Ling

AU - Lai, Ying Hsiu

AU - Hwang, Jiann Loung

AU - Juan, Chi Chang

PY - 2005/1/17

Y1 - 2005/1/17

N2 - Resistin, a hormone secreted by adipocytes, is suggested to be an important link between obesity and diabetes. The aim of this study was to evaluate the regulatory effect of estrogen on adipocyte resistin gene expression in ovariectomized (OVX) rats and in isolated rat adipocytes in vitro. Subcutaneous injection of estradiol benzoate reduced resistin mRNA levels in adipocytes isolated from the inguinal, parametrial, perirenal, retroperitoneal, or periovarian fat deposits of OVX rats, while an in vitro study showed that estradiol treatment decreased resistin mRNA levels in cultured rat periovarian fat adipocytes. Results of Western blotting analysis also showed that estrogen decreased adipose resistin contents in vivo and in vitro. These data suggest that estrogen is a pivotal negative regulator of resistin gene expression.

AB - Resistin, a hormone secreted by adipocytes, is suggested to be an important link between obesity and diabetes. The aim of this study was to evaluate the regulatory effect of estrogen on adipocyte resistin gene expression in ovariectomized (OVX) rats and in isolated rat adipocytes in vitro. Subcutaneous injection of estradiol benzoate reduced resistin mRNA levels in adipocytes isolated from the inguinal, parametrial, perirenal, retroperitoneal, or periovarian fat deposits of OVX rats, while an in vitro study showed that estradiol treatment decreased resistin mRNA levels in cultured rat periovarian fat adipocytes. Results of Western blotting analysis also showed that estrogen decreased adipose resistin contents in vivo and in vitro. These data suggest that estrogen is a pivotal negative regulator of resistin gene expression.

KW - Adipocyte

KW - Estrogen

KW - Ovariectomy

KW - Resistin

UR - http://www.scopus.com/inward/record.url?scp=11844302893&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11844302893&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2004.12.010

DO - 10.1016/j.febslet.2004.12.010

M3 - Article

C2 - 15642357

AN - SCOPUS:11844302893

SN - 0014-5793

VL - 579

SP - 449

EP - 454

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

Resistin mRNA levels are downregulated by estrogen in vivo and in vitro

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this