Research of biocompatibility on bioactive films fabricated using oxygen plasma immersion ion implantation

Wei Fang Lee; Hsi Jen Chiang; Che Tong Lin; Keng Liang Ou; Pei Wen Peng

doi:10.1515/polyeng-2013-0221

Research of biocompatibility on bioactive films fabricated using oxygen plasma immersion ion implantation

Wei Fang Lee, Hsi Jen Chiang, Che Tong Lin, Keng Liang Ou, Pei Wen Peng

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

In the present study, a nanoporous, biocompatible titanium dioxide (TiO₂) film was formed on the surface of titanium, using oxygen plasma immersion ion implantation (OPIII), and the influence of this film on the bio-functionalization, including the proliferation and differentiation properties of MG-63 osteoblast-like cells, was analyzed and investigated. The OPIII-treated surface was characterized by X-ray photoelectron, which showed that a TiO_x layer was formed on Ti substrates. This TiO_x surface exhibited nanoscale surface roughness in the form of nanoporous structures. The results also revealed that MG-63 cells expressed increased proliferation on the OPIII-treated surface as compared with the untreated Ti substrate. The Ti specimens treated with plasma energy of 1 kW revealed better expression of alkaline phosphatase (ALP) activity and showed higher average surface roughness than untreated specimens. Thus, it can be concluded that bioactivity of Ti implants can potentially be improved by OPIII.

Original language	English
Pages (from-to)	247-252
Number of pages	6
Journal	Journal of Polymer Engineering
Volume	34
Issue number	3
DOIs	https://doi.org/10.1515/polyeng-2013-0221
Publication status	Published - May 1 2014

Keywords

alkaline phosphatase
plasma oxidation
titanium

ASJC Scopus subject areas

General Chemical Engineering
Polymers and Plastics
Materials Chemistry

Access to Document

10.1515/polyeng-2013-0221

Cite this

@article{a5fe28a86b284cea8f55c3ed3a81b390,

title = "Research of biocompatibility on bioactive films fabricated using oxygen plasma immersion ion implantation",

abstract = "In the present study, a nanoporous, biocompatible titanium dioxide (TiO2) film was formed on the surface of titanium, using oxygen plasma immersion ion implantation (OPIII), and the influence of this film on the bio-functionalization, including the proliferation and differentiation properties of MG-63 osteoblast-like cells, was analyzed and investigated. The OPIII-treated surface was characterized by X-ray photoelectron, which showed that a TiOx layer was formed on Ti substrates. This TiOx surface exhibited nanoscale surface roughness in the form of nanoporous structures. The results also revealed that MG-63 cells expressed increased proliferation on the OPIII-treated surface as compared with the untreated Ti substrate. The Ti specimens treated with plasma energy of 1 kW revealed better expression of alkaline phosphatase (ALP) activity and showed higher average surface roughness than untreated specimens. Thus, it can be concluded that bioactivity of Ti implants can potentially be improved by OPIII.",

keywords = "alkaline phosphatase, plasma oxidation, titanium",

author = "Lee, {Wei Fang} and Chiang, {Hsi Jen} and Lin, {Che Tong} and Ou, {Keng Liang} and Peng, {Pei Wen}",

note = "Funding Information: Acknowledgments: The authors would like to thank Yu-Hao Chan and Yi-Yu Chen for participation in experiments. The authors also acknowledge financial support of research by the project of Cathy General Hospital – Taipei Medical University, under the grant number of 100CGH-TMU-09.",

year = "2014",

month = may,

day = "1",

doi = "10.1515/polyeng-2013-0221",

language = "English",

volume = "34",

pages = "247--252",

journal = "Journal of Polymer Engineering",

issn = "0334-6447",

publisher = "Walter de Gruyter GmbH & Co. KG",

number = "3",

}

TY - JOUR

T1 - Research of biocompatibility on bioactive films fabricated using oxygen plasma immersion ion implantation

AU - Lee, Wei Fang

AU - Chiang, Hsi Jen

AU - Lin, Che Tong

AU - Ou, Keng Liang

AU - Peng, Pei Wen

N1 - Funding Information: Acknowledgments: The authors would like to thank Yu-Hao Chan and Yi-Yu Chen for participation in experiments. The authors also acknowledge financial support of research by the project of Cathy General Hospital – Taipei Medical University, under the grant number of 100CGH-TMU-09.

PY - 2014/5/1

Y1 - 2014/5/1

N2 - In the present study, a nanoporous, biocompatible titanium dioxide (TiO2) film was formed on the surface of titanium, using oxygen plasma immersion ion implantation (OPIII), and the influence of this film on the bio-functionalization, including the proliferation and differentiation properties of MG-63 osteoblast-like cells, was analyzed and investigated. The OPIII-treated surface was characterized by X-ray photoelectron, which showed that a TiOx layer was formed on Ti substrates. This TiOx surface exhibited nanoscale surface roughness in the form of nanoporous structures. The results also revealed that MG-63 cells expressed increased proliferation on the OPIII-treated surface as compared with the untreated Ti substrate. The Ti specimens treated with plasma energy of 1 kW revealed better expression of alkaline phosphatase (ALP) activity and showed higher average surface roughness than untreated specimens. Thus, it can be concluded that bioactivity of Ti implants can potentially be improved by OPIII.

AB - In the present study, a nanoporous, biocompatible titanium dioxide (TiO2) film was formed on the surface of titanium, using oxygen plasma immersion ion implantation (OPIII), and the influence of this film on the bio-functionalization, including the proliferation and differentiation properties of MG-63 osteoblast-like cells, was analyzed and investigated. The OPIII-treated surface was characterized by X-ray photoelectron, which showed that a TiOx layer was formed on Ti substrates. This TiOx surface exhibited nanoscale surface roughness in the form of nanoporous structures. The results also revealed that MG-63 cells expressed increased proliferation on the OPIII-treated surface as compared with the untreated Ti substrate. The Ti specimens treated with plasma energy of 1 kW revealed better expression of alkaline phosphatase (ALP) activity and showed higher average surface roughness than untreated specimens. Thus, it can be concluded that bioactivity of Ti implants can potentially be improved by OPIII.

KW - alkaline phosphatase

KW - plasma oxidation

KW - titanium

UR - http://www.scopus.com/inward/record.url?scp=84899809823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899809823&partnerID=8YFLogxK

U2 - 10.1515/polyeng-2013-0221

DO - 10.1515/polyeng-2013-0221

M3 - Article

AN - SCOPUS:84899809823

SN - 0334-6447

VL - 34

SP - 247

EP - 252

JO - Journal of Polymer Engineering

JF - Journal of Polymer Engineering

IS - 3

ER -

Research of biocompatibility on bioactive films fabricated using oxygen plasma immersion ion implantation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this