Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke

I. Kuan Wang; Chung Hsiang Liu; Tzung Hai Yen; Jiann Shing Jeng; Sheng Feng Sung; Pai Hao Huang; Jie Yuan Li; Yu Sun; Cheng Yu Wei; Li Ming Lien; I. Ju Tsai; Fung Chang Sung; Chung Y. Hsu; Chung Hsiang Liu; Chon Haw Tsai; Wei Shih Huang; Chung Ta Lu; Tzung Chang Tsai; Chun Hung Tseng; Kang Hsu Lin; Woei Cherng Shyu; Yu Wan Yang; Yen Liang Liu; Der Yang Cho; Chun Chung Chen; Sung Chun Tang; Li Kai Tsai; Shin Joe Yeh; Chih Hao Chen; Hsin Hsi Tsai; Han Jung Chen; Kan Lu; Shih Pin Hsu; Hung Chang Kuo; Jung Chi Tsou; Yan Tang Wang; Yi Cheng Tai; Meng Tsang Hsieh; Po Chao Liliang; Cheng Loong Liang; Hao Kuang Wang; Yu Tun Tsai; Kuo Wei Wang; Jui Sheng Chen; Po Yuan Chen; Yi Ching Wang; Pi Shan Sung; Han Chieh Hsieh; Hui Chen Su; Hou Chang Chiu; Jia-Ying Sung; Chin-I Chen; Lung Chan; Shu-Ping Chao; Chih-Shan Huang; Jing-Er Lee; Hsing-Yu Weng; Hao-Wen Teng; Chih-Shan Huang; Rey-Yue Yuan; Jau-Jiuan Sheu; Jia Ming Yu; Chun Sum Ho; Ting-Chun Lin; Chaur-Jong Hu; Nai-Fang Chi

doi:10.1016/j.atherosclerosis.2017.11.029

Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke

I. Kuan Wang, Chung Hsiang Liu, Tzung Hai Yen, Jiann Shing Jeng, Sheng Feng Sung, Pai Hao Huang, Jie Yuan Li, Yu Sun, Cheng Yu Wei, Li Ming Lien, I. Ju Tsai, Fung Chang Sung, Chung Y. Hsu, Chung Hsiang Liu, Chon Haw Tsai, Wei Shih Huang, Chung Ta Lu, Tzung Chang Tsai, Chun Hung Tseng, Kang Hsu LinWoei Cherng Shyu, Yu Wan Yang, Yen Liang Liu, Der Yang Cho, Chun Chung Chen, Sung Chun Tang, Li Kai Tsai, Shin Joe Yeh, Chih Hao Chen, Hsin Hsi Tsai, Han Jung Chen, Kan Lu, Shih Pin Hsu, Hung Chang Kuo, Jung Chi Tsou, Yan Tang Wang, Yi Cheng Tai, Meng Tsang Hsieh, Po Chao Liliang, Cheng Loong Liang, Hao Kuang Wang, Yu Tun Tsai, Kuo Wei Wang, Jui Sheng Chen, Po Yuan Chen, Yi Ching Wang, Pi Shan Sung, Han Chieh Hsieh, Hui Chen Su, Hou Chang Chiu, Jia-Ying Sung, Chin-I Chen, Lung Chan, Shu-Ping Chao, Chih-Shan Huang, Jing-Er Lee, Hsing-Yu Weng, Hao-Wen Teng, Chih-Shan Huang, Rey-Yue Yuan, Jau-Jiuan Sheu, Jia Ming Yu, Chun Sum Ho, Ting-Chun Lin, Chaur-Jong Hu, Nai-Fang Chi

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Background and aims: Renal dysfunction is a potent risk factor for cardiovascular diseases, including stroke. This study aimed to evaluate the impact of admission estimated glomerular filtration rate (eGFR) levels on short-term (1-month) and long-term (1-year) mortality in patients with acute ischemic stroke. Methods: From the Taiwan Stroke Registry data, we classified ischemic stroke patients, identified from April 2006 to December 2015, into 5 groups by eGFR at admission: ≥ 90, 60–89, 30–59, 15–29, and <15 mL/min/1.73 m² or on dialysis. Risks of 1-month mortality and 1-year mortality after ischemic stroke were investigated by the eGFR level. Results: Among 52,732 ischemic stroke patients, 1480 died within one month. The 1-month mortality rate was over 5-fold greater in patients with eGFR <15 mL/min/1.73 m² or dialysis than in patients with eGFR ≥90 mL/min/1.73 m² (2.88 versus 0.56 per 1000 person-days). The adjusted hazard ratio (HR) of 1-month mortality increased from 1.31 (95% CI = 1.08–1.59) for patients with eGFR 60–89 mL/min/1.73 m² to 2.33 (95% CI = 1.80–3.02) for patients with eGFR < 15 mL/min/1.73 m² or on dialysis. 3226 patients died within one year. The adjusted HR of mortality increased from 1.38 (95% CI = 1.21–1.59) for patients with eGFR 60–89 mL/min/1.73 m² to 2.60 (95% CI 2.18–3.10) for patients with eGFR < 15 mL/min/1.73 m² or on dialysis, compared to patients with eGFR ≥ 90 mL/min/1.73 m². Conclusions: After acute ischemic stroke, patients with reduced eGFR are at elevated risks of short-term and long-term deaths in a graded relationship.

Original language	English
Pages (from-to)	288-293
Number of pages	6
Journal	Atherosclerosis
Volume	269
DOIs	https://doi.org/10.1016/j.atherosclerosis.2017.11.029
Publication status	Published - Feb 1 2018

Keywords

Estimated glomerular filtration rate
Ischemic stroke
Mortality
Renal function

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.atherosclerosis.2017.11.029

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Wang, I. K., Liu, C. H., Yen, T. H., Jeng, J. S., Sung, S. F., Huang, P. H., Li, J. Y., Sun, Y., Wei, C. Y., Lien, L. M., Tsai, I. J., Sung, F. C., Hsu, C. Y., Liu, C. H., Tsai, C. H., Huang, W. S., Lu, C. T., Tsai, T. C., Tseng, C. H., ... Chi, N.-F. (2018). Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke. Atherosclerosis, 269, 288-293. https://doi.org/10.1016/j.atherosclerosis.2017.11.029

Wang, IK, Liu, CH, Yen, TH, Jeng, JS, Sung, SF, Huang, PH, Li, JY, Sun, Y, Wei, CY, Lien, LM, Tsai, IJ, Sung, FC, Hsu, CY, Liu, CH, Tsai, CH, Huang, WS, Lu, CT, Tsai, TC, Tseng, CH, Lin, KH, Shyu, WC, Yang, YW, Liu, YL, Cho, DY, Chen, CC, Tang, SC, Tsai, LK, Yeh, SJ, Chen, CH, Tsai, HH, Chen, HJ, Lu, K, Hsu, SP, Kuo, HC, Tsou, JC, Wang, YT, Tai, YC, Hsieh, MT, Liliang, PC, Liang, CL, Wang, HK, Tsai, YT, Wang, KW, Chen, JS, Chen, PY, Wang, YC, Sung, PS, Hsieh, HC, Su, HC, Chiu, HC, Sung, J-Y , Chen, C-I , Chan, L , Chao, S-P , Huang, C-S , Lee, J-E , Weng, H-Y, Teng, H-W, Huang, C-S , Yuan, R-Y , Sheu, J-J, Yu, JM, Ho, CS, Lin, T-C, Hu, C-J & Chi, N-F 2018, 'Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke', Atherosclerosis, vol. 269, pp. 288-293. https://doi.org/10.1016/j.atherosclerosis.2017.11.029

@article{7839299018d7405d885d33c252e54c76,

title = "Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke",

abstract = "Background and aims: Renal dysfunction is a potent risk factor for cardiovascular diseases, including stroke. This study aimed to evaluate the impact of admission estimated glomerular filtration rate (eGFR) levels on short-term (1-month) and long-term (1-year) mortality in patients with acute ischemic stroke. Methods: From the Taiwan Stroke Registry data, we classified ischemic stroke patients, identified from April 2006 to December 2015, into 5 groups by eGFR at admission: ≥ 90, 60–89, 30–59, 15–29, and <15 mL/min/1.73 m2 or on dialysis. Risks of 1-month mortality and 1-year mortality after ischemic stroke were investigated by the eGFR level. Results: Among 52,732 ischemic stroke patients, 1480 died within one month. The 1-month mortality rate was over 5-fold greater in patients with eGFR <15 mL/min/1.73 m2 or dialysis than in patients with eGFR ≥90 mL/min/1.73 m2 (2.88 versus 0.56 per 1000 person-days). The adjusted hazard ratio (HR) of 1-month mortality increased from 1.31 (95\% CI = 1.08–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.33 (95\% CI = 1.80–3.02) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis. 3226 patients died within one year. The adjusted HR of mortality increased from 1.38 (95\% CI = 1.21–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.60 (95\% CI 2.18–3.10) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis, compared to patients with eGFR ≥ 90 mL/min/1.73 m2. Conclusions: After acute ischemic stroke, patients with reduced eGFR are at elevated risks of short-term and long-term deaths in a graded relationship.",

keywords = "Estimated glomerular filtration rate, Ischemic stroke, Mortality, Renal function",

author = "Wang, \{I. Kuan\} and Liu, \{Chung Hsiang\} and Yen, \{Tzung Hai\} and Jeng, \{Jiann Shing\} and Sung, \{Sheng Feng\} and Huang, \{Pai Hao\} and Li, \{Jie Yuan\} and Yu Sun and Wei, \{Cheng Yu\} and Lien, \{Li Ming\} and Tsai, \{I. Ju\} and Sung, \{Fung Chang\} and Hsu, \{Chung Y.\} and Liu, \{Chung Hsiang\} and Tsai, \{Chon Haw\} and Huang, \{Wei Shih\} and Lu, \{Chung Ta\} and Tsai, \{Tzung Chang\} and Tseng, \{Chun Hung\} and Lin, \{Kang Hsu\} and Shyu, \{Woei Cherng\} and Yang, \{Yu Wan\} and Liu, \{Yen Liang\} and Cho, \{Der Yang\} and Chen, \{Chun Chung\} and Tang, \{Sung Chun\} and Tsai, \{Li Kai\} and Yeh, \{Shin Joe\} and Chen, \{Chih Hao\} and Tsai, \{Hsin Hsi\} and Chen, \{Han Jung\} and Kan Lu and Hsu, \{Shih Pin\} and Kuo, \{Hung Chang\} and Tsou, \{Jung Chi\} and Wang, \{Yan Tang\} and Tai, \{Yi Cheng\} and Hsieh, \{Meng Tsang\} and Liliang, \{Po Chao\} and Liang, \{Cheng Loong\} and Wang, \{Hao Kuang\} and Tsai, \{Yu Tun\} and Wang, \{Kuo Wei\} and Chen, \{Jui Sheng\} and Chen, \{Po Yuan\} and Wang, \{Yi Ching\} and Sung, \{Pi Shan\} and Hsieh, \{Han Chieh\} and Su, \{Hui Chen\} and Chiu, \{Hou Chang\} and Jia-Ying Sung and Chin-I Chen and Lung Chan and Shu-Ping Chao and Chih-Shan Huang and Jing-Er Lee and Hsing-Yu Weng and Hao-Wen Teng and Chih-Shan Huang and Rey-Yue Yuan and Jau-Jiuan Sheu and Yu, \{Jia Ming\} and Ho, \{Chun Sum\} and Ting-Chun Lin and Chaur-Jong Hu and Nai-Fang Chi",

note = "Funding Information: The present study was supported by the research laboratory of pediatrics, Children's Hospital of China Medical University ( DMR-105-041 ), China Medical University Hospital ( DMR-106-025 and DMR-107-026 ), Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence ( MOHW106-TDU-B-212-113004 ), Academia Sinica Taiwan Biobank, Stroke Biosignature Project ( BM10601010036 ); Taiwan Clinical Trial Consortium for Stroke ( MOST 106-2321-B-039-005 ); Tseng-Lien Lin Foundation, Taichung, Taiwan ; Taiwan Brain Disease Foundation, Taipei, Taiwan ; and Katsuzo and Kiyo Aoshima Memorial Funds, Japan . Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2018",

month = feb,

day = "1",

doi = "10.1016/j.atherosclerosis.2017.11.029",

language = "English",

volume = "269",

pages = "288--293",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke

AU - Wang, I. Kuan

AU - Liu, Chung Hsiang

AU - Yen, Tzung Hai

AU - Jeng, Jiann Shing

AU - Sung, Sheng Feng

AU - Huang, Pai Hao

AU - Li, Jie Yuan

AU - Sun, Yu

AU - Wei, Cheng Yu

AU - Lien, Li Ming

AU - Tsai, I. Ju

AU - Sung, Fung Chang

AU - Hsu, Chung Y.

AU - Liu, Chung Hsiang

AU - Tsai, Chon Haw

AU - Huang, Wei Shih

AU - Lu, Chung Ta

AU - Tsai, Tzung Chang

AU - Tseng, Chun Hung

AU - Lin, Kang Hsu

AU - Shyu, Woei Cherng

AU - Yang, Yu Wan

AU - Liu, Yen Liang

AU - Cho, Der Yang

AU - Chen, Chun Chung

AU - Tang, Sung Chun

AU - Tsai, Li Kai

AU - Yeh, Shin Joe

AU - Chen, Chih Hao

AU - Tsai, Hsin Hsi

AU - Chen, Han Jung

AU - Lu, Kan

AU - Hsu, Shih Pin

AU - Kuo, Hung Chang

AU - Tsou, Jung Chi

AU - Wang, Yan Tang

AU - Tai, Yi Cheng

AU - Hsieh, Meng Tsang

AU - Liliang, Po Chao

AU - Liang, Cheng Loong

AU - Wang, Hao Kuang

AU - Tsai, Yu Tun

AU - Wang, Kuo Wei

AU - Chen, Jui Sheng

AU - Chen, Po Yuan

AU - Wang, Yi Ching

AU - Sung, Pi Shan

AU - Hsieh, Han Chieh

AU - Su, Hui Chen

AU - Chiu, Hou Chang

AU - Sung, Jia-Ying

AU - Chen, Chin-I

AU - Chan, Lung

AU - Chao, Shu-Ping

AU - Huang, Chih-Shan

AU - Lee, Jing-Er

AU - Weng, Hsing-Yu

AU - Teng, Hao-Wen

AU - Huang, Chih-Shan

AU - Yuan, Rey-Yue

AU - Sheu, Jau-Jiuan

AU - Yu, Jia Ming

AU - Ho, Chun Sum

AU - Lin, Ting-Chun

AU - Hu, Chaur-Jong

AU - Chi, Nai-Fang

N1 - Funding Information: The present study was supported by the research laboratory of pediatrics, Children's Hospital of China Medical University ( DMR-105-041 ), China Medical University Hospital ( DMR-106-025 and DMR-107-026 ), Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence ( MOHW106-TDU-B-212-113004 ), Academia Sinica Taiwan Biobank, Stroke Biosignature Project ( BM10601010036 ); Taiwan Clinical Trial Consortium for Stroke ( MOST 106-2321-B-039-005 ); Tseng-Lien Lin Foundation, Taichung, Taiwan ; Taiwan Brain Disease Foundation, Taipei, Taiwan ; and Katsuzo and Kiyo Aoshima Memorial Funds, Japan . Publisher Copyright: © 2017 Elsevier B.V.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background and aims: Renal dysfunction is a potent risk factor for cardiovascular diseases, including stroke. This study aimed to evaluate the impact of admission estimated glomerular filtration rate (eGFR) levels on short-term (1-month) and long-term (1-year) mortality in patients with acute ischemic stroke. Methods: From the Taiwan Stroke Registry data, we classified ischemic stroke patients, identified from April 2006 to December 2015, into 5 groups by eGFR at admission: ≥ 90, 60–89, 30–59, 15–29, and <15 mL/min/1.73 m2 or on dialysis. Risks of 1-month mortality and 1-year mortality after ischemic stroke were investigated by the eGFR level. Results: Among 52,732 ischemic stroke patients, 1480 died within one month. The 1-month mortality rate was over 5-fold greater in patients with eGFR <15 mL/min/1.73 m2 or dialysis than in patients with eGFR ≥90 mL/min/1.73 m2 (2.88 versus 0.56 per 1000 person-days). The adjusted hazard ratio (HR) of 1-month mortality increased from 1.31 (95% CI = 1.08–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.33 (95% CI = 1.80–3.02) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis. 3226 patients died within one year. The adjusted HR of mortality increased from 1.38 (95% CI = 1.21–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.60 (95% CI 2.18–3.10) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis, compared to patients with eGFR ≥ 90 mL/min/1.73 m2. Conclusions: After acute ischemic stroke, patients with reduced eGFR are at elevated risks of short-term and long-term deaths in a graded relationship.

AB - Background and aims: Renal dysfunction is a potent risk factor for cardiovascular diseases, including stroke. This study aimed to evaluate the impact of admission estimated glomerular filtration rate (eGFR) levels on short-term (1-month) and long-term (1-year) mortality in patients with acute ischemic stroke. Methods: From the Taiwan Stroke Registry data, we classified ischemic stroke patients, identified from April 2006 to December 2015, into 5 groups by eGFR at admission: ≥ 90, 60–89, 30–59, 15–29, and <15 mL/min/1.73 m2 or on dialysis. Risks of 1-month mortality and 1-year mortality after ischemic stroke were investigated by the eGFR level. Results: Among 52,732 ischemic stroke patients, 1480 died within one month. The 1-month mortality rate was over 5-fold greater in patients with eGFR <15 mL/min/1.73 m2 or dialysis than in patients with eGFR ≥90 mL/min/1.73 m2 (2.88 versus 0.56 per 1000 person-days). The adjusted hazard ratio (HR) of 1-month mortality increased from 1.31 (95% CI = 1.08–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.33 (95% CI = 1.80–3.02) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis. 3226 patients died within one year. The adjusted HR of mortality increased from 1.38 (95% CI = 1.21–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.60 (95% CI 2.18–3.10) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis, compared to patients with eGFR ≥ 90 mL/min/1.73 m2. Conclusions: After acute ischemic stroke, patients with reduced eGFR are at elevated risks of short-term and long-term deaths in a graded relationship.

KW - Estimated glomerular filtration rate

KW - Ischemic stroke

KW - Mortality

KW - Renal function

UR - https://www.scopus.com/pages/publications/85039456839

UR - https://www.scopus.com/inward/citedby.url?scp=85039456839&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2017.11.029

DO - 10.1016/j.atherosclerosis.2017.11.029

M3 - Article

AN - SCOPUS:85039456839

SN - 0021-9150

VL - 269

SP - 288

EP - 293

JO - Atherosclerosis

JF - Atherosclerosis

ER -

Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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