Renal dysfunction by BK virus infection is correlated with activated T cell level in renal transplantation

Ming Che Lee; Ming Chi Lu; Ning Sheng Lai; Su Chin Liu; Hui Chun Yu; Teng Yi Lin; Shueh Ping Hung; Hsien Bin Huang; Wen Yao Yin

doi:10.1016/j.jss.2012.04.064

Renal dysfunction by BK virus infection is correlated with activated T cell level in renal transplantation

Ming Che Lee, Ming Chi Lu, Ning Sheng Lai, Su Chin Liu, Hui Chun Yu, Teng Yi Lin, Shueh Ping Hung, Hsien Bin Huang, Wen Yao Yin

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Background: BK virus (BKV) is known to be associated with nephropathy. Here, we investigated the relationships between BKV levels, T-cell activation, and kidney function in kidney transplant recipients. Materials and methods: In renal transplant patients and controls, urine BKV levels were detected by quantitative real-time PCR, and the percentage of activated T lymphocytes in blood was determined by flow cytometry. The correlations between viral load, activated T cell percentage, and renal function were determined. Results: Urine BKV viral loads and the activated T cell percentage were significantly elevated in transplant recipients. Correlational analysis indicated that transplant recipients that had BKV levels of more than 10⁶ copies/mL and an activated T lymphocyte percentage of less than 20% were likely to have poor renal function. Conclusions: Urine BKV levels and the percentage of activated T lymphocytes can be used as clinical indices to optimize the dosage of immunosuppressive drugs.

Original language	English
Pages (from-to)	330-336
Number of pages	7
Journal	Journal of Surgical Research
Volume	180
Issue number	2
DOIs	https://doi.org/10.1016/j.jss.2012.04.064
Publication status	Published - Apr 2013
Externally published	Yes

Keywords

Activated T cell
BK virus
Immunosuppression
Renal dysfunction

ASJC Scopus subject areas

Surgery

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10.1016/j.jss.2012.04.064

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@article{0226f3a322d74817a97de040ecb45862,

title = "Renal dysfunction by BK virus infection is correlated with activated T cell level in renal transplantation",

abstract = "Background: BK virus (BKV) is known to be associated with nephropathy. Here, we investigated the relationships between BKV levels, T-cell activation, and kidney function in kidney transplant recipients. Materials and methods: In renal transplant patients and controls, urine BKV levels were detected by quantitative real-time PCR, and the percentage of activated T lymphocytes in blood was determined by flow cytometry. The correlations between viral load, activated T cell percentage, and renal function were determined. Results: Urine BKV viral loads and the activated T cell percentage were significantly elevated in transplant recipients. Correlational analysis indicated that transplant recipients that had BKV levels of more than 106 copies/mL and an activated T lymphocyte percentage of less than 20% were likely to have poor renal function. Conclusions: Urine BKV levels and the percentage of activated T lymphocytes can be used as clinical indices to optimize the dosage of immunosuppressive drugs.",

keywords = "Activated T cell, BK virus, Immunosuppression, Renal dysfunction",

author = "Lee, {Ming Che} and Lu, {Ming Chi} and Lai, {Ning Sheng} and Liu, {Su Chin} and Yu, {Hui Chun} and Lin, {Teng Yi} and Hung, {Shueh Ping} and Huang, {Hsien Bin} and Yin, {Wen Yao}",

note = "Funding Information: This work was supported in part by grant TCRD-I9607-01 from the Buddhist Tzu Chi General Hospital , Chia-Yi, Taiwan.",

year = "2013",

month = apr,

doi = "10.1016/j.jss.2012.04.064",

language = "English",

volume = "180",

pages = "330--336",

journal = "Journal of Surgical Research",

issn = "0022-4804",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Renal dysfunction by BK virus infection is correlated with activated T cell level in renal transplantation

AU - Lee, Ming Che

AU - Lu, Ming Chi

AU - Lai, Ning Sheng

AU - Liu, Su Chin

AU - Yu, Hui Chun

AU - Lin, Teng Yi

AU - Hung, Shueh Ping

AU - Huang, Hsien Bin

AU - Yin, Wen Yao

N1 - Funding Information: This work was supported in part by grant TCRD-I9607-01 from the Buddhist Tzu Chi General Hospital , Chia-Yi, Taiwan.

PY - 2013/4

Y1 - 2013/4

N2 - Background: BK virus (BKV) is known to be associated with nephropathy. Here, we investigated the relationships between BKV levels, T-cell activation, and kidney function in kidney transplant recipients. Materials and methods: In renal transplant patients and controls, urine BKV levels were detected by quantitative real-time PCR, and the percentage of activated T lymphocytes in blood was determined by flow cytometry. The correlations between viral load, activated T cell percentage, and renal function were determined. Results: Urine BKV viral loads and the activated T cell percentage were significantly elevated in transplant recipients. Correlational analysis indicated that transplant recipients that had BKV levels of more than 106 copies/mL and an activated T lymphocyte percentage of less than 20% were likely to have poor renal function. Conclusions: Urine BKV levels and the percentage of activated T lymphocytes can be used as clinical indices to optimize the dosage of immunosuppressive drugs.

AB - Background: BK virus (BKV) is known to be associated with nephropathy. Here, we investigated the relationships between BKV levels, T-cell activation, and kidney function in kidney transplant recipients. Materials and methods: In renal transplant patients and controls, urine BKV levels were detected by quantitative real-time PCR, and the percentage of activated T lymphocytes in blood was determined by flow cytometry. The correlations between viral load, activated T cell percentage, and renal function were determined. Results: Urine BKV viral loads and the activated T cell percentage were significantly elevated in transplant recipients. Correlational analysis indicated that transplant recipients that had BKV levels of more than 106 copies/mL and an activated T lymphocyte percentage of less than 20% were likely to have poor renal function. Conclusions: Urine BKV levels and the percentage of activated T lymphocytes can be used as clinical indices to optimize the dosage of immunosuppressive drugs.

KW - Activated T cell

KW - BK virus

KW - Immunosuppression

KW - Renal dysfunction

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JO - Journal of Surgical Research

JF - Journal of Surgical Research

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Renal dysfunction by BK virus infection is correlated with activated T cell level in renal transplantation

Abstract

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