Relationship between matrix metalloproteinase-2 activity and cystatin C levels in patients with hepatic disease

Tzy Yen Chen; Yih Shou Hsieh; Chi Chieh Yang; Chi Ping Wang; Shun Fa Yang; Yan Wen Cheng; Hui Ling Chiou

doi:10.1016/j.clinbiochem.2005.03.005

Relationship between matrix metalloproteinase-2 activity and cystatin C levels in patients with hepatic disease

Tzy Yen Chen, Yih Shou Hsieh, Chi Chieh Yang, Chi Ping Wang, Shun Fa Yang, Yan Wen Cheng, Hui Ling Chiou

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Objectives: A direct relationship between cystatin C levels and the severity of hepatic disease has been revealed in our previous study. This study was aimed to consider whether a correlation exists between matrix metalloproteinases (MMPs), which have been proven to be involved in liver cirrhosis, and cystatin C to reflect the severity of hepatic disease. Design and Methods: A total of 154 consecutive patients with various liver diseases were recruited to determine their serum levels of cystatin C, MMP-2 and-9, together with other hepatic parameters. These were compared with 40 normal controls. Results: Average levels of MMP-2 and cystatin C were significantly higher in patients while MMP-9 was significantly lower, as compared to controls. A linear regression analysis has revealed a direct relationship between cystatin C and MMP-2 (Y = 83.39 + 270.56X, R = 0.38, P <0.001), as well as between MMP-2 and the severity of liver diseases. Conclusion: This is the first study to demonstrate a correlation between cystatin C and MMP-2, suggesting that there may be certain interactions between cystatin C and MMP-2 in patients with hepatic diseases.

Original language	English
Pages (from-to)	632-638
Number of pages	7
Journal	Clinical Biochemistry
Volume	38
Issue number	7
DOIs	https://doi.org/10.1016/j.clinbiochem.2005.03.005
Publication status	Published - Jul 2005
Externally published	Yes

Keywords

Cystatin C
Hepatic disease
MMP-2

ASJC Scopus subject areas

Clinical Biochemistry

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10.1016/j.clinbiochem.2005.03.005

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@article{d78ada2b97564766832f309e7a43b11b,

title = "Relationship between matrix metalloproteinase-2 activity and cystatin C levels in patients with hepatic disease",

abstract = "Objectives: A direct relationship between cystatin C levels and the severity of hepatic disease has been revealed in our previous study. This study was aimed to consider whether a correlation exists between matrix metalloproteinases (MMPs), which have been proven to be involved in liver cirrhosis, and cystatin C to reflect the severity of hepatic disease. Design and Methods: A total of 154 consecutive patients with various liver diseases were recruited to determine their serum levels of cystatin C, MMP-2 and-9, together with other hepatic parameters. These were compared with 40 normal controls. Results: Average levels of MMP-2 and cystatin C were significantly higher in patients while MMP-9 was significantly lower, as compared to controls. A linear regression analysis has revealed a direct relationship between cystatin C and MMP-2 (Y = 83.39 + 270.56X, R = 0.38, P <0.001), as well as between MMP-2 and the severity of liver diseases. Conclusion: This is the first study to demonstrate a correlation between cystatin C and MMP-2, suggesting that there may be certain interactions between cystatin C and MMP-2 in patients with hepatic diseases.",

keywords = "Cystatin C, Hepatic disease, MMP-2",

author = "Chen, {Tzy Yen} and Hsieh, {Yih Shou} and Yang, {Chi Chieh} and Wang, {Chi Ping} and Yang, {Shun Fa} and Cheng, {Yan Wen} and Chiou, {Hui Ling}",

note = "Funding Information: This work was supported by a grant from Chung Shan Medical University (CSMU 91-OM-B-025).",

year = "2005",

month = jul,

doi = "10.1016/j.clinbiochem.2005.03.005",

language = "English",

volume = "38",

pages = "632--638",

journal = "Clinical Biochemistry",

issn = "0009-9120",

publisher = "Elsevier Inc.",

number = "7",

}

TY - JOUR

T1 - Relationship between matrix metalloproteinase-2 activity and cystatin C levels in patients with hepatic disease

AU - Chen, Tzy Yen

AU - Hsieh, Yih Shou

AU - Yang, Chi Chieh

AU - Wang, Chi Ping

AU - Yang, Shun Fa

AU - Cheng, Yan Wen

AU - Chiou, Hui Ling

N1 - Funding Information: This work was supported by a grant from Chung Shan Medical University (CSMU 91-OM-B-025).

PY - 2005/7

Y1 - 2005/7

N2 - Objectives: A direct relationship between cystatin C levels and the severity of hepatic disease has been revealed in our previous study. This study was aimed to consider whether a correlation exists between matrix metalloproteinases (MMPs), which have been proven to be involved in liver cirrhosis, and cystatin C to reflect the severity of hepatic disease. Design and Methods: A total of 154 consecutive patients with various liver diseases were recruited to determine their serum levels of cystatin C, MMP-2 and-9, together with other hepatic parameters. These were compared with 40 normal controls. Results: Average levels of MMP-2 and cystatin C were significantly higher in patients while MMP-9 was significantly lower, as compared to controls. A linear regression analysis has revealed a direct relationship between cystatin C and MMP-2 (Y = 83.39 + 270.56X, R = 0.38, P <0.001), as well as between MMP-2 and the severity of liver diseases. Conclusion: This is the first study to demonstrate a correlation between cystatin C and MMP-2, suggesting that there may be certain interactions between cystatin C and MMP-2 in patients with hepatic diseases.

AB - Objectives: A direct relationship between cystatin C levels and the severity of hepatic disease has been revealed in our previous study. This study was aimed to consider whether a correlation exists between matrix metalloproteinases (MMPs), which have been proven to be involved in liver cirrhosis, and cystatin C to reflect the severity of hepatic disease. Design and Methods: A total of 154 consecutive patients with various liver diseases were recruited to determine their serum levels of cystatin C, MMP-2 and-9, together with other hepatic parameters. These were compared with 40 normal controls. Results: Average levels of MMP-2 and cystatin C were significantly higher in patients while MMP-9 was significantly lower, as compared to controls. A linear regression analysis has revealed a direct relationship between cystatin C and MMP-2 (Y = 83.39 + 270.56X, R = 0.38, P <0.001), as well as between MMP-2 and the severity of liver diseases. Conclusion: This is the first study to demonstrate a correlation between cystatin C and MMP-2, suggesting that there may be certain interactions between cystatin C and MMP-2 in patients with hepatic diseases.

KW - Cystatin C

KW - Hepatic disease

KW - MMP-2

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Relationship between matrix metalloproteinase-2 activity and cystatin C levels in patients with hepatic disease

Abstract

Keywords

ASJC Scopus subject areas

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