Relationship between electroencephalogram slow-wave magnitude and heart rate variability during sleep in rats

Cheryl C H Yang; Fu Zen Shaw; Ching J. Lai; Chi Wan Lai; Terry B J Kuo

doi:10.1016/S0304-3940(02)01200-4

Relationship between electroencephalogram slow-wave magnitude and heart rate variability during sleep in rats

Cheryl C H Yang
, Fu Zen Shaw
, Ching J. Lai
, Chi Wan Lai
, Terry B J Kuo

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

To explore whether depth of sleep is related to changes in autonomic control in rats, continuous power-spectral analysis of electroencephalogram (EEG) and heart rate variability (HRV) was performed in unanesthetized rats during normal daytime sleep. Quiet sleep (QS) was associated with an increase in high-frequency power of HRV (0.6-2.4 Hz, HF) but a decrease in low-frequency power (0.06-0.6 Hz) to HF ratio (LF/HF) compared with awakening. During QS, LF/HF was significantly and negatively correlated with delta power of EEG (0.5-4.0 Hz), whereas mean R-R interval and HF were not. As in humans, cardiac sympathetic regulation in rats is negatively related to the depth of sleep during QS, although vagal regulation is not. Our methodology offers a parallel way of studying the interaction between cerebral cortical and autonomic functions in rats.

Original language	English
Pages (from-to)	21-24
Number of pages	4
Journal	Neuroscience Letters
Volume	336
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(02)01200-4
Publication status	Published - Jan 9 2003
Externally published	Yes

Keywords

Autonomic nervous system
Electroencephalogram
Heart rate variability
Parasympathetic activity
Power-spectral analysis
Sleep
Slow wave
Sympathetic activity

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(02)01200-4

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title = "Relationship between electroencephalogram slow-wave magnitude and heart rate variability during sleep in rats",

abstract = "To explore whether depth of sleep is related to changes in autonomic control in rats, continuous power-spectral analysis of electroencephalogram (EEG) and heart rate variability (HRV) was performed in unanesthetized rats during normal daytime sleep. Quiet sleep (QS) was associated with an increase in high-frequency power of HRV (0.6-2.4 Hz, HF) but a decrease in low-frequency power (0.06-0.6 Hz) to HF ratio (LF/HF) compared with awakening. During QS, LF/HF was significantly and negatively correlated with delta power of EEG (0.5-4.0 Hz), whereas mean R-R interval and HF were not. As in humans, cardiac sympathetic regulation in rats is negatively related to the depth of sleep during QS, although vagal regulation is not. Our methodology offers a parallel way of studying the interaction between cerebral cortical and autonomic functions in rats.",

keywords = "Autonomic nervous system, Electroencephalogram, Heart rate variability, Parasympathetic activity, Power-spectral analysis, Sleep, Slow wave, Sympathetic activity",

author = "Yang, \{Cheryl C H\} and Shaw, \{Fu Zen\} and Lai, \{Ching J.\} and Lai, \{Chi Wan\} and Kuo, \{Terry B J\}",

note = "Funding Information: We thank Ms S.T. Liu and S.F. Kuo for their excellent technical support. This study was supported by the National Science Council (Taiwan) through grants NSC-89-2745-P-320-001 and NSC-89-2320-B-320-026.",

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doi = "10.1016/S0304-3940(02)01200-4",

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AU - Yang, Cheryl C H

AU - Shaw, Fu Zen

AU - Lai, Ching J.

AU - Lai, Chi Wan

AU - Kuo, Terry B J

N1 - Funding Information: We thank Ms S.T. Liu and S.F. Kuo for their excellent technical support. This study was supported by the National Science Council (Taiwan) through grants NSC-89-2745-P-320-001 and NSC-89-2320-B-320-026.

PY - 2003/1/9

Y1 - 2003/1/9

N2 - To explore whether depth of sleep is related to changes in autonomic control in rats, continuous power-spectral analysis of electroencephalogram (EEG) and heart rate variability (HRV) was performed in unanesthetized rats during normal daytime sleep. Quiet sleep (QS) was associated with an increase in high-frequency power of HRV (0.6-2.4 Hz, HF) but a decrease in low-frequency power (0.06-0.6 Hz) to HF ratio (LF/HF) compared with awakening. During QS, LF/HF was significantly and negatively correlated with delta power of EEG (0.5-4.0 Hz), whereas mean R-R interval and HF were not. As in humans, cardiac sympathetic regulation in rats is negatively related to the depth of sleep during QS, although vagal regulation is not. Our methodology offers a parallel way of studying the interaction between cerebral cortical and autonomic functions in rats.

AB - To explore whether depth of sleep is related to changes in autonomic control in rats, continuous power-spectral analysis of electroencephalogram (EEG) and heart rate variability (HRV) was performed in unanesthetized rats during normal daytime sleep. Quiet sleep (QS) was associated with an increase in high-frequency power of HRV (0.6-2.4 Hz, HF) but a decrease in low-frequency power (0.06-0.6 Hz) to HF ratio (LF/HF) compared with awakening. During QS, LF/HF was significantly and negatively correlated with delta power of EEG (0.5-4.0 Hz), whereas mean R-R interval and HF were not. As in humans, cardiac sympathetic regulation in rats is negatively related to the depth of sleep during QS, although vagal regulation is not. Our methodology offers a parallel way of studying the interaction between cerebral cortical and autonomic functions in rats.

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KW - Electroencephalogram

KW - Heart rate variability

KW - Parasympathetic activity

KW - Power-spectral analysis

KW - Sleep

KW - Slow wave

KW - Sympathetic activity

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Relationship between electroencephalogram slow-wave magnitude and heart rate variability during sleep in rats

Abstract

Keywords

ASJC Scopus subject areas

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