Relationship between Dry Eye Disease and Dyslipidemia: A Systematic Review

Tzu Hao Wang, Yuan Jen Tsai, Yuan Hung Wang, Chien Liang Wu, I. Chan Lin

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Background: Dyslipidemia has been suggested to be associated with the occurrence of dry eye disease (DED). However, whether dyslipidemia is responsible for the development of DED remains unclear. In this systematic review, we explored the relationship between DED and dyslipidemia by using quantitative data. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a comprehensive literature search in several databases, including PubMed, Embase, Cochrane Library, Web of Science, and Google Scholar, and obtained six relevant studies. Results: Our findings indicated that the majority of the selected studies reported a statistically significant association between dyslipidemia and DED, particularly in women. However, our quantitative analysis revealed that only two studies reported statistically significant differences in total cholesterol and high-density lipoprotein cholesterol values. Conclusion: No statistically significant differences exist in the majority of lipid profile parameters between individuals with and without DED, but there is a statistically significant association between dyslipidemia and DED.

Original languageEnglish
Article number6631
JournalJournal of Clinical Medicine
Issue number20
Publication statusPublished - Oct 2023


  • dry eye
  • dry eye disease
  • dry eye syndrome
  • dyslipidemia
  • hypercholesterolemia
  • hyperlipidemia
  • hypertriglyceridemia
  • systematic disease

ASJC Scopus subject areas

  • General Medicine


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