Relapse of Graves' disease after successful allogeneic bone marrow transplantation

L. T. Hsiao, J. H. Liu, C. C. Yen, W. S. Wang, F. S. Fan, T. J. Chiou, P. M. Chen

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


As shown in many reports, allogeneic BMT can help cure autoimmune diseases. Conversely, we present a 24-year-old woman with Graves' disease, which was diagnosed just before BMT for CML. The Graves' disease remitted immediately after BMT but relapsed 18 months later. Since the donor was free from thyroid diseases and the patient showed a rapid shift to complete donor chimerism after BMT, the autoimmune problem seemed neither to arise directly from the donor nor simply from the recipient's residual lymphocytes. On the contrary, it was most likely compounded by chronic GVHD as suggested by the accompanying GVHD symptoms and the absolute donor karyotype in bone marrow cells. A Graves' disease-susceptible HLA allele was also shared between recipient and donor, possibly enhancing the chances of this condition developing. Thus, allogeneic BMT may facilitate relapses in autoimmune diseases as well as alleviating them.

Original languageEnglish
Pages (from-to)1151-1153
Number of pages3
JournalBone Marrow Transplantation
Issue number12
Publication statusPublished - 2001
Externally publishedYes


  • Allogeneic BMT
  • Chronic GVHD
  • Graves' disease
  • HLA

ASJC Scopus subject areas

  • Hematology
  • Transplantation


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