Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells

Hsiao Mei Chao; Teh Wei Wang; Edward Chern; Shan Hui Hsu

doi:10.4251/wjgo.v14.i4.748

Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells

Hsiao Mei Chao, Teh Wei Wang, Edward Chern, Shan Hui Hsu

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The properties of cancer stem cells (CSCs), such as self-renewal, drug resistance, and metastasis, have been indicated to be responsible for the poor prognosis of patients with colon cancers. The epigenetic regulatory network plays a crucial role in CSC properties. Regulatory non-coding RNA (ncRNA), including microRNAs, long noncoding RNAs, and circular RNAs, have an important influence on cell physiopathology. They modulate cells by regulating gene expression in different ways. This review discusses the basic characteristics and the physiological functions of colorectal cancer (CRC) stem cells. Elucidation of these ncRNAs will help us understand the pathological mechanism of CRC progression, and they could become a new target for cancer treatment.

Original language	English
Pages (from-to)	748-764
Number of pages	17
Journal	World Journal of Gastrointestinal Oncology
Volume	14
Issue number	4
DOIs	https://doi.org/10.4251/wjgo.v14.i4.748
Publication status	Published - Apr 15 2022

Keywords

Cancer stem cell
Circular rna
Colorectal cancer
Long-non coding rna
Microrna
Regulatory rnas
Stemness

ASJC Scopus subject areas

Oncology
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4251/wjgo.v14.i4.748

Cite this

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title = "Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells",

abstract = "The properties of cancer stem cells (CSCs), such as self-renewal, drug resistance, and metastasis, have been indicated to be responsible for the poor prognosis of patients with colon cancers. The epigenetic regulatory network plays a crucial role in CSC properties. Regulatory non-coding RNA (ncRNA), including microRNAs, long noncoding RNAs, and circular RNAs, have an important influence on cell physiopathology. They modulate cells by regulating gene expression in different ways. This review discusses the basic characteristics and the physiological functions of colorectal cancer (CRC) stem cells. Elucidation of these ncRNAs will help us understand the pathological mechanism of CRC progression, and they could become a new target for cancer treatment.",

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AU - Chao, Hsiao Mei

AU - Wang, Teh Wei

AU - Chern, Edward

AU - Hsu, Shan Hui

PY - 2022/4/15

Y1 - 2022/4/15

N2 - The properties of cancer stem cells (CSCs), such as self-renewal, drug resistance, and metastasis, have been indicated to be responsible for the poor prognosis of patients with colon cancers. The epigenetic regulatory network plays a crucial role in CSC properties. Regulatory non-coding RNA (ncRNA), including microRNAs, long noncoding RNAs, and circular RNAs, have an important influence on cell physiopathology. They modulate cells by regulating gene expression in different ways. This review discusses the basic characteristics and the physiological functions of colorectal cancer (CRC) stem cells. Elucidation of these ncRNAs will help us understand the pathological mechanism of CRC progression, and they could become a new target for cancer treatment.

AB - The properties of cancer stem cells (CSCs), such as self-renewal, drug resistance, and metastasis, have been indicated to be responsible for the poor prognosis of patients with colon cancers. The epigenetic regulatory network plays a crucial role in CSC properties. Regulatory non-coding RNA (ncRNA), including microRNAs, long noncoding RNAs, and circular RNAs, have an important influence on cell physiopathology. They modulate cells by regulating gene expression in different ways. This review discusses the basic characteristics and the physiological functions of colorectal cancer (CRC) stem cells. Elucidation of these ncRNAs will help us understand the pathological mechanism of CRC progression, and they could become a new target for cancer treatment.

KW - Cancer stem cell

KW - Circular rna

KW - Colorectal cancer

KW - Long-non coding rna

KW - Microrna

KW - Regulatory rnas

KW - Stemness

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Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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