TY - JOUR
T1 - Regulation of tumor growth and metastasis
T2 - the role of tumor microenvironment
AU - Goubran, Hadi Alphonse
AU - Kotb, Rami R
AU - Stakiw, Julie
AU - Emara, Mohamed E
AU - Burnouf, Thierry Pierre Robert
PY - 2014
Y1 - 2014
N2 - The presence of abnormal cells with malignant potential or neoplastic characteristics is a relatively common phenomenon. The interaction of these abnormal cells with their microenvironment is essential for tumor development, protection from the body's immune or defence mechanisms, later progression and the development of life-threatening or metastatic disease. The tumor microenvironment is a collective term that includes the tumor's surrounding and supportive stroma, the different effectors of the immune system, blood platelets, hormones and other humoral factors. A better understanding of the interplay between the tumor cells and its microenvironment can provide efficient tools for cancer management, as well as better prevention, screening and risk assessment protocols.
AB - The presence of abnormal cells with malignant potential or neoplastic characteristics is a relatively common phenomenon. The interaction of these abnormal cells with their microenvironment is essential for tumor development, protection from the body's immune or defence mechanisms, later progression and the development of life-threatening or metastatic disease. The tumor microenvironment is a collective term that includes the tumor's surrounding and supportive stroma, the different effectors of the immune system, blood platelets, hormones and other humoral factors. A better understanding of the interplay between the tumor cells and its microenvironment can provide efficient tools for cancer management, as well as better prevention, screening and risk assessment protocols.
KW - Journal Article
KW - Review
U2 - 10.4137/CGM.S11285
DO - 10.4137/CGM.S11285
M3 - Article
C2 - 24926201
SN - 1179-0644
VL - 7
SP - 9
EP - 18
JO - Cancer growth and metastasis
JF - Cancer growth and metastasis
ER -
