Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana hayata

Chia Chun Yu; Ching Ruey Hsieh; George Hsiao; Pi Yu Chen; Meng Lun Chang; Hwa Wen Yin; Zong-Huei Li; Ching Kuo Lee

doi:10.3390/molecules17022082

Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana hayata

Chia Chun Yu, Ching Ruey Hsieh, George Hsiao, Pi Yu Chen, Meng Lun Chang, Hwa Wen Yin, Zong-Huei Li, Ching Kuo Lee

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3, 14-dione (6). The structures of compounds 1-6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3-5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.

Original language	English
Pages (from-to)	2082-2090
Number of pages	9
Journal	Molecules
Volume	17
Issue number	2
DOIs	https://doi.org/10.3390/molecules17022082
Publication status	Published - Feb 2012

Keywords

Abietane diterpene
Euphorbia formosana
HT-1080
MMP-2, -9

ASJC Scopus subject areas

Drug Discovery
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Physical and Theoretical Chemistry
Pharmaceutical Science
Organic Chemistry

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10.3390/molecules17022082

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title = "Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana hayata",

abstract = "Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3, 14-dione (6). The structures of compounds 1-6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3-5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.",

keywords = "Abietane diterpene, Euphorbia formosana, HT-1080, MMP-2, -9",

author = "Yu, {Chia Chun} and Hsieh, {Ching Ruey} and George Hsiao and Chen, {Pi Yu} and Chang, {Meng Lun} and Yin, {Hwa Wen} and Zong-Huei Li and Lee, {Ching Kuo}",

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AU - Yu, Chia Chun

AU - Hsieh, Ching Ruey

AU - Hsiao, George

AU - Chen, Pi Yu

AU - Chang, Meng Lun

AU - Yin, Hwa Wen

AU - Li, Zong-Huei

AU - Lee, Ching Kuo

PY - 2012/2

Y1 - 2012/2

N2 - Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3, 14-dione (6). The structures of compounds 1-6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3-5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.

AB - Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3, 14-dione (6). The structures of compounds 1-6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3-5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.

KW - Abietane diterpene

KW - Euphorbia formosana

KW - HT-1080

KW - MMP-2, -9

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Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana hayata

Abstract

Keywords

ASJC Scopus subject areas

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