Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3, 14-dione (6). The structures of compounds 1-6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3-5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.

Original languageEnglish
Pages (from-to)2082-2090
Number of pages9
Issue number2
Publication statusPublished - Feb 2012


  • Abietane diterpene
  • Euphorbia formosana
  • HT-1080
  • MMP-2, -9

ASJC Scopus subject areas

  • Organic Chemistry


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