Regenerative effect of expired platelet concentrates in human therapy: An update

Thierry Burnouf, Hadi Alphonse Goubran

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


There is concrete evidence that outdated allogeneic platelet concentrates not used for transfusion are valuable sources of functional trophic factors, including growth factors, cytokines, chemokines, anti-inflammatory and antioxidant molecules. Such outdated platelet concentrates can be used to produce human platelet lysates (HPL), a proven potent growth supplement for the propagation of therapeutic human cells, including mesenchymal stromal cells. On-going preclinical studies demonstrate the interest in such “outdated” allogeneic platelet lysates for treating corneal diseases and neurological disorders of the central nervous system, potentially opening vital therapeutic perspectives.

Original languageEnglish
Article number103363
JournalTransfusion and Apheresis Science
Issue number1
Publication statusAccepted/In press - 2022


  • Cell therapy
  • Neurology
  • Platelet lysate
  • Platelets
  • Regenerative medicine
  • Stem cells

ASJC Scopus subject areas

  • Hematology


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