Regenerative effect of expired platelet concentrates in human therapy: An update

There is concrete evidence that outdated allogeneic platelet concentrates not used for transfusion are valuable sources of functional trophic factors, including growth factors, cytokines, chemokines, anti-inflammatory and antioxidant molecules. Such outdated platelet concentrates can be used to produce human platelet lysates (HPL), a proven potent growth supplement for the propagation of therapeutic human cells, including mesenchymal stromal cells. On-going preclinical studies demonstrate the interest in such “outdated” allogeneic platelet lysates for treating corneal diseases and neurological disorders of the central nervous system, potentially opening vital therapeutic perspectives.