Abstract
Original language | English |
---|---|
Journal | Frontiers in Behavioral Neuroscience |
Volume | 8 |
Issue number | AUG |
DOIs | |
Publication status | Published - 2014 |
Keywords
- Bulimia
- Eating disorders
- fMRI
- Functional connectivity
- Resting state
- Somatosensory network
- adult
- age
- article
- awareness
- body mass
- bulimia
- clinical article
- controlled study
- cuneus
- depression
- female
- functional magnetic resonance imaging
- human
- mental disease
- occipital gyrus
- posterior cingulate
- prediction
- resting state functional connectivity
- resting state network
- somatosensory cortex
- symptomatology
- visual cortex
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In: Frontiers in Behavioral Neuroscience, Vol. 8, No. AUG, 2014.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Reduced resting-state functional connectivity of the somatosensory cortex predicts psychopathological symptoms in women with bulimia nervosa
AU - Lavagnino, Luca
AU - Amianto, Federico
AU - D'Agata, Federico
AU - Huang, Zirui
AU - Mortara, Paolo
AU - Abbate-Daga, Giovanni
AU - Marzola, Enrica
AU - Spalatro, Angela
AU - Fassino, Secondo
AU - Northoff, Georg Franz Josef
N1 - Cited By :3 Export Date: 11 May 2016 Correspondence Address: Lavagnino, L.; Department of Neuroscience, AOU San Giovanni Battista, Turin, Italy; email: [email protected] References: Abbate-Daga, G., Gramaglia, C., Amianto, F., Marzola, E., Fassino, F., Attachment insecurity, personality, and body dissatisfaction in eating disorders (2010) J. Nerv. Ment. Dis., 198, pp. 520-524. , doi: 10. 1097/NMD. 0b013e3181e4c6f7; (2000) Diagnostic and Statistical Manual of Mental Disorders, , 4th Edition, Text Revision (DSM-IV-TR). 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PY - 2014
Y1 - 2014
N2 - Background: Alterations in the resting-state functional connectivity (rs-FC) of several brain networks have been demonstrated in eating disorders. However, very few studies are currently available on brain network dysfunctions in bulimia nervosa (BN).The somatosensory network is central in processing body-related stimuli and it may be altered in BN. The present study therefore aimed to investigate rs-FC in the somatosensory network in bulimic women. Methods: Sixteen medication-free women with BN (age = 23 ± 5 years) and 18 matched controls (age = 23 ± 3 years) underwent a functional magnetic resonance resting-state scan and assessment of eating disorder symptoms. Within-network and seed-based functional connectivity analyses were conducted to assess rs-FC within the somatosensory network and to other areas of the brain. Results: Bulimia nervosa patients showed a decreased rs-FC both within the somatosensory network (t = 9.0, df = 1, P = 0.005) and with posterior cingulate cortex and two visual areas (the right middle occipital gyrus and the right cuneus) (P = 0.05 corrected for multiple comparison). The rs-FC of the left paracentral lobule with the right middle occipital gyrus correlated with psychopathology measures like bulimia (r = -0.4; P = 0.02) and interoceptive awareness (r = -0.4; P = 0.01). Analyses were conducted using age, BMI (body mass index), and depressive symptoms as covariates. Conclusion: Our findings show a specific alteration of the rs-FC of the somatosensory cortex in BN patients, which correlates with eating disorder symptoms. The region in the right middle occipital gyrus is implicated in body processing and is known as extrastriate body area (EBA). The connectivity between the somatosensory cortex and the EBA might be related to dysfunctions in body image processing. The results should be considered preliminary due to the small sample size. © 2014 Lavagnino, Amianto, D'Agata, Huang, Mortara, Abbate-Daga, Marzola, Spalatro, Fassino and Northoff.
AB - Background: Alterations in the resting-state functional connectivity (rs-FC) of several brain networks have been demonstrated in eating disorders. However, very few studies are currently available on brain network dysfunctions in bulimia nervosa (BN).The somatosensory network is central in processing body-related stimuli and it may be altered in BN. The present study therefore aimed to investigate rs-FC in the somatosensory network in bulimic women. Methods: Sixteen medication-free women with BN (age = 23 ± 5 years) and 18 matched controls (age = 23 ± 3 years) underwent a functional magnetic resonance resting-state scan and assessment of eating disorder symptoms. Within-network and seed-based functional connectivity analyses were conducted to assess rs-FC within the somatosensory network and to other areas of the brain. Results: Bulimia nervosa patients showed a decreased rs-FC both within the somatosensory network (t = 9.0, df = 1, P = 0.005) and with posterior cingulate cortex and two visual areas (the right middle occipital gyrus and the right cuneus) (P = 0.05 corrected for multiple comparison). The rs-FC of the left paracentral lobule with the right middle occipital gyrus correlated with psychopathology measures like bulimia (r = -0.4; P = 0.02) and interoceptive awareness (r = -0.4; P = 0.01). Analyses were conducted using age, BMI (body mass index), and depressive symptoms as covariates. Conclusion: Our findings show a specific alteration of the rs-FC of the somatosensory cortex in BN patients, which correlates with eating disorder symptoms. The region in the right middle occipital gyrus is implicated in body processing and is known as extrastriate body area (EBA). The connectivity between the somatosensory cortex and the EBA might be related to dysfunctions in body image processing. The results should be considered preliminary due to the small sample size. © 2014 Lavagnino, Amianto, D'Agata, Huang, Mortara, Abbate-Daga, Marzola, Spalatro, Fassino and Northoff.
KW - Bulimia
KW - Eating disorders
KW - fMRI
KW - Functional connectivity
KW - Resting state
KW - Somatosensory network
KW - adult
KW - age
KW - article
KW - awareness
KW - body mass
KW - bulimia
KW - clinical article
KW - controlled study
KW - cuneus
KW - depression
KW - female
KW - functional magnetic resonance imaging
KW - human
KW - mental disease
KW - occipital gyrus
KW - posterior cingulate
KW - prediction
KW - resting state functional connectivity
KW - resting state network
KW - somatosensory cortex
KW - symptomatology
KW - visual cortex
U2 - 10.3389/fnbeh.2014.00270
DO - 10.3389/fnbeh.2014.00270
M3 - Article
SN - 1662-5153
VL - 8
JO - Frontiers in Behavioral Neuroscience
JF - Frontiers in Behavioral Neuroscience
IS - AUG
ER -