Reduced expression of tocopherol-associated protein (TAP/Sec14L2) in human breast cancer.

X. Wang; Jing Ni; Chen Long Hsu; Sharlin Johnykutty; Ping Tang; Yuan Soon Ho; Chia Hwa Lee; Shuyuang Yeh

Reduced expression of tocopherol-associated protein (TAP/Sec14L2) in human breast cancer.

X. Wang, Jing Ni, Chen Long Hsu, Sharlin Johnykutty, Ping Tang, Yuan Soon Ho, Chia Hwa Lee, Shuyuang Yeh

Research output: Contribution to journal › Article › peer-review

Abstract

We show that TAP/Sec14L2 had a high expression in normal/benign breast, prostate, and liver tissues as compared to lung, colon, and kidney. Its expression was downregulated in breast cancer cell lines shown by quantitative-PCR. Further, 57% of 141 human invasive breast carcinomas had no or markedly reduced TAP/Sec14L2 expression by immunohistochemical staining, and the rate increased to 80% in high grade invasive carcinomas (p <.01). This downregulation of TAP/Sec14L2 was also present in ductal carcinoma in situ (DCIS) associated with invasive carcinomas. These findings raise the possibility that TAP/Sec14L2 may serve as a tumor suppressor in breast carcinogenesis.

Original language	English
Pages (from-to)	971-977
Number of pages	7
Journal	Cancer Investigation
Volume	27
Issue number	10
Publication status	Published - Dec 2009
Externally published	Yes

ASJC Scopus subject areas

Cancer Research
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Reduced expression of tocopherol-associated protein (TAP/Sec14L2) in human breast cancer.",

abstract = "We show that TAP/Sec14L2 had a high expression in normal/benign breast, prostate, and liver tissues as compared to lung, colon, and kidney. Its expression was downregulated in breast cancer cell lines shown by quantitative-PCR. Further, 57% of 141 human invasive breast carcinomas had no or markedly reduced TAP/Sec14L2 expression by immunohistochemical staining, and the rate increased to 80% in high grade invasive carcinomas (p <.01). This downregulation of TAP/Sec14L2 was also present in ductal carcinoma in situ (DCIS) associated with invasive carcinomas. These findings raise the possibility that TAP/Sec14L2 may serve as a tumor suppressor in breast carcinogenesis.",

author = "X. Wang and Jing Ni and Hsu, {Chen Long} and Sharlin Johnykutty and Ping Tang and Ho, {Yuan Soon} and Lee, {Chia Hwa} and Shuyuang Yeh",

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T1 - Reduced expression of tocopherol-associated protein (TAP/Sec14L2) in human breast cancer.

AU - Wang, X.

AU - Ni, Jing

AU - Hsu, Chen Long

AU - Johnykutty, Sharlin

AU - Tang, Ping

AU - Ho, Yuan Soon

AU - Lee, Chia Hwa

AU - Yeh, Shuyuang

PY - 2009/12

Y1 - 2009/12

N2 - We show that TAP/Sec14L2 had a high expression in normal/benign breast, prostate, and liver tissues as compared to lung, colon, and kidney. Its expression was downregulated in breast cancer cell lines shown by quantitative-PCR. Further, 57% of 141 human invasive breast carcinomas had no or markedly reduced TAP/Sec14L2 expression by immunohistochemical staining, and the rate increased to 80% in high grade invasive carcinomas (p <.01). This downregulation of TAP/Sec14L2 was also present in ductal carcinoma in situ (DCIS) associated with invasive carcinomas. These findings raise the possibility that TAP/Sec14L2 may serve as a tumor suppressor in breast carcinogenesis.

AB - We show that TAP/Sec14L2 had a high expression in normal/benign breast, prostate, and liver tissues as compared to lung, colon, and kidney. Its expression was downregulated in breast cancer cell lines shown by quantitative-PCR. Further, 57% of 141 human invasive breast carcinomas had no or markedly reduced TAP/Sec14L2 expression by immunohistochemical staining, and the rate increased to 80% in high grade invasive carcinomas (p <.01). This downregulation of TAP/Sec14L2 was also present in ductal carcinoma in situ (DCIS) associated with invasive carcinomas. These findings raise the possibility that TAP/Sec14L2 may serve as a tumor suppressor in breast carcinogenesis.

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Reduced expression of tocopherol-associated protein (TAP/Sec14L2) in human breast cancer.

Abstract

ASJC Scopus subject areas

UN SDGs

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