Reciprocal Translocation in Small-Cell Sarcomas

Jean Pierre de Chadarevian, Michel Vekemans, Thomas A. Seemayer, Jacqueline Whang-Peng, Timothy J. Triche, Turid Knutsen, James Miser, Mark A. Israel

Research output: Contribution to journalLetterpeer-review

32 Citations (Scopus)


To the Editor: In the August 30 issue, Whang-Peng and colleagues report finding the translocation rcp(11;22)(q24;q12) in tumor cells and cell lines from two patients with peripheral neuroepithelioma.1 This observation was of considerable interest since the same chromosomal abnormalities were recently described in Ewing's sarcoma,2,3 a neoplasm easily confused with undifferentiated peripheral neuroectodermal malignant tumors. In the context of these reports, we wish to describe the cytogenetic findings in a malignant peripheral neuroectodermal tumor initially diagnosed as Ewing's sarcoma. An 11-year-old girl presented with a soft-tissue mass involving the left hemithorax and fifth rib. Biopsy revealed a malignant monomorphic poorly…

Original languageEnglish
Pages (from-to)1702-1703
Number of pages2
JournalNew England Journal of Medicine
Issue number26
Publication statusPublished - Dec 27 1984
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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