Reciprocal relationship of Tn/NF-κB and sTn as an indicator of the prognosis of oral squamous cell carcinoma

Chi Yu Lin, Jar Yi Ho, Meng Ti Hsieh, H. L. Chiang, Jei Min Chuang, Jacqueline Whang-Peng, Yun Ching Chang, Yi Han Tseng, Su Feng Chen, Shin Nieh, Jau-Lang Hwang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Aims: In order to determine whether the expression of tumour-associated carbohydrate antigens (Tn/sTn) and a representative inflammation marker, nuclear factor-κB (NF-κB), is associated with the invasiveness of oral squamous cell carcinoma (OSCC), this study has attempted to investigate the correlation of the aforementioned markers with the well-established invasive pattern grading score (IPGS) and clinicopathological parameters. Methods and results: Specimens from 143 OSCC patients with classified clinicopathological parameters and IPGS were stained immunohistochemically using anti-Tn, sTn and NF-κB antibodies. Our results showed that the expression of both Tn and NF-κB was correlated positively with staging (P = 0.036; P = 0.015), recurrence (P <0.001; P <0.001) and distant metastasis (P = 0.005; P = 0.009), as well as with IPGS, while the expression of sTn was correlated inversely. In addition, poor survival was associated with overexpression of Tn and NF-κB but not with expression of sTn. Conclusions: Our results indicate that a reciprocal relationship between Tn and sTn expression may serve as a reliable indicator for OSCC prognostic evaluation. In addition, expression of Tn rather than sTn may play an important role in deeply invasive OSCC via regulation of NF-κB signalling.

Original languageEnglish
Pages (from-to)713-721
Number of pages9
Issue number5
Publication statusPublished - Apr 2014


  • Invasive pattern grading score
  • Nuclear factor-κB
  • Oral squamous cell carcinoma
  • Tumour-associated carbohydrate antigen

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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