RC-RNase-induced cell death in estrogen receptor positive breast tumors through down-regulation of Bcl-2 and estrogen receptor

Hsu Hung Tseng; Yung Luen Yu; Yi Lin Sophia Chen; Jia Hui Chen; Chu Lin Chou; Tsun Yung Kuo; Jaang Jiun Wang; Ming Chieh Lee; Ting Han Huang; Mark Hung Chih Chen; Giou Teng Yiang

doi:10.3892/or.2010.1114

RC-RNase-induced cell death in estrogen receptor positive breast tumors through down-regulation of Bcl-2 and estrogen receptor

Hsu Hung Tseng, Yung Luen Yu, Yi Lin Sophia Chen, Jia Hui Chen, Chu Lin Chou, Tsun Yung Kuo, Jaang Jiun Wang, Ming Chieh Lee, Ting Han Huang, Mark Hung Chih Chen, Giou Teng Yiang

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

RC-RNase exerts anti-cancer effects on many tumors. However, the mechanisms by which RC-RNase induces cytotoxicity in different tumor cells are unclear. Currently, estrogen receptor (ER)-positive and negative breast tumors are treated with RC-RNase. Our data demonstrate that RC-RNase induces cell death on ER-positive but not on ER-negative breast tumors. This study also shows that downregulation of ER and Bcl-2 is found on RC-RNase-treated ER-positive breast tumors. Additionally, Bcl-2 ovexpression can prevent ER-positive breast tumors from cell death treated with RC-RNase. In summary, this study demonstrates that RC-RNase-induced cell death of ER-positive breast tumors is through regulation of ER and Bcl-2.

Original language	English
Pages (from-to)	849-853
Number of pages	5
Journal	Oncology Reports
Volume	25
Issue number	3
DOIs	https://doi.org/10.3892/or.2010.1114
Publication status	Published - Mar 1 2011
Externally published	Yes

Keywords

Bcl-2
Breast tumor
Estrogen receptor

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/or.2010.1114

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title = "RC-RNase-induced cell death in estrogen receptor positive breast tumors through down-regulation of Bcl-2 and estrogen receptor",

abstract = "RC-RNase exerts anti-cancer effects on many tumors. However, the mechanisms by which RC-RNase induces cytotoxicity in different tumor cells are unclear. Currently, estrogen receptor (ER)-positive and negative breast tumors are treated with RC-RNase. Our data demonstrate that RC-RNase induces cell death on ER-positive but not on ER-negative breast tumors. This study also shows that downregulation of ER and Bcl-2 is found on RC-RNase-treated ER-positive breast tumors. Additionally, Bcl-2 ovexpression can prevent ER-positive breast tumors from cell death treated with RC-RNase. In summary, this study demonstrates that RC-RNase-induced cell death of ER-positive breast tumors is through regulation of ER and Bcl-2.",

keywords = "Bcl-2, Breast tumor, Estrogen receptor",

author = "Tseng, {Hsu Hung} and Yu, {Yung Luen} and Chen, {Yi Lin Sophia} and Chen, {Jia Hui} and Chou, {Chu Lin} and Kuo, {Tsun Yung} and Wang, {Jaang Jiun} and Lee, {Ming Chieh} and Huang, {Ting Han} and Chen, {Mark Hung Chih} and Yiang, {Giou Teng}",

year = "2011",

month = mar,

day = "1",

doi = "10.3892/or.2010.1114",

language = "English",

volume = "25",

pages = "849--853",

journal = "Oncology Reports",

issn = "1021-335X",

publisher = "Spandidos Publications",

number = "3",

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TY - JOUR

T1 - RC-RNase-induced cell death in estrogen receptor positive breast tumors through down-regulation of Bcl-2 and estrogen receptor

AU - Tseng, Hsu Hung

AU - Yu, Yung Luen

AU - Chen, Yi Lin Sophia

AU - Chen, Jia Hui

AU - Chou, Chu Lin

AU - Kuo, Tsun Yung

AU - Wang, Jaang Jiun

AU - Lee, Ming Chieh

AU - Huang, Ting Han

AU - Chen, Mark Hung Chih

AU - Yiang, Giou Teng

PY - 2011/3/1

Y1 - 2011/3/1

N2 - RC-RNase exerts anti-cancer effects on many tumors. However, the mechanisms by which RC-RNase induces cytotoxicity in different tumor cells are unclear. Currently, estrogen receptor (ER)-positive and negative breast tumors are treated with RC-RNase. Our data demonstrate that RC-RNase induces cell death on ER-positive but not on ER-negative breast tumors. This study also shows that downregulation of ER and Bcl-2 is found on RC-RNase-treated ER-positive breast tumors. Additionally, Bcl-2 ovexpression can prevent ER-positive breast tumors from cell death treated with RC-RNase. In summary, this study demonstrates that RC-RNase-induced cell death of ER-positive breast tumors is through regulation of ER and Bcl-2.

AB - RC-RNase exerts anti-cancer effects on many tumors. However, the mechanisms by which RC-RNase induces cytotoxicity in different tumor cells are unclear. Currently, estrogen receptor (ER)-positive and negative breast tumors are treated with RC-RNase. Our data demonstrate that RC-RNase induces cell death on ER-positive but not on ER-negative breast tumors. This study also shows that downregulation of ER and Bcl-2 is found on RC-RNase-treated ER-positive breast tumors. Additionally, Bcl-2 ovexpression can prevent ER-positive breast tumors from cell death treated with RC-RNase. In summary, this study demonstrates that RC-RNase-induced cell death of ER-positive breast tumors is through regulation of ER and Bcl-2.

KW - Bcl-2

KW - Breast tumor

KW - Estrogen receptor

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U2 - 10.3892/or.2010.1114

DO - 10.3892/or.2010.1114

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SN - 1021-335X

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SP - 849

EP - 853

JO - Oncology Reports

JF - Oncology Reports

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ER -

RC-RNase-induced cell death in estrogen receptor positive breast tumors through down-regulation of Bcl-2 and estrogen receptor

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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