TY - JOUR
T1 - Ratio of dietary ω-3 and ω-6 fatty acids—independent determinants of muscle mass—in hemodialysis patients with diabetes
AU - Wong, Te Chih
AU - Chen, Yu Tong
AU - Wu, Pei Yu
AU - Chen, Tzen Wen
AU - Chen, Hsi Hsien
AU - Chen, Tso Hsiao
AU - Hsu, Yung Ho
AU - Yang, Shwu Huey
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Objective: n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential nutrients in the human diet and possibly affect muscle mass. We evaluated the association between the dietary ratios of n-3 and n-6 PUFAs and muscle mass, indicated as skeletal muscle mass (SMM) and appendicular skeletal muscle mass (ASM), in patients with diabetes undergoing hemodialysis (HD). Methods: In this cross-sectional study, data on 69 patients with diabetes who underwent standard HD therapy were analyzed. For estimating muscle mass, anthropometric and bioelectrical impedance analyses were conducted following dialysis. In addition, routine laboratory and 3-d dietary data were obtained. The adequate intake (AI) cut-off for n-3 PUFAs was 1.6 g/d and 1.1 g/d for male and female patients, respectively. Results: The average age of the participants was 63.0 ± 10.4 y. The mean ratios of n-3/n-6 PUFA intake, n-6/n-3 PUFA intake, SMM, and ASM of the patients were 0.13 ± 0.07, 9.4 ± 6.4, 24.6 ± 5.4 kg, and 18.3 ± 4.6 kg, respectively. Patients who had AI of n-3 PUFAs had significantly higher SMM and ASM than did their counterparts. Linear and stepwise multivariable adjustment analyses revealed that insulin resistance and the n-6/n-3 PUFA ratio were the independent deleterious determinants of ASM normalized to height in HD patients. Conclusions: Patients with AI of n-3 PUFAs had total-body SMM and ASM that were more appropriate. A higher dietary ratio of n-6/n-3 PUFAs was associated with reduced muscle mass in HD patients.
AB - Objective: n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential nutrients in the human diet and possibly affect muscle mass. We evaluated the association between the dietary ratios of n-3 and n-6 PUFAs and muscle mass, indicated as skeletal muscle mass (SMM) and appendicular skeletal muscle mass (ASM), in patients with diabetes undergoing hemodialysis (HD). Methods: In this cross-sectional study, data on 69 patients with diabetes who underwent standard HD therapy were analyzed. For estimating muscle mass, anthropometric and bioelectrical impedance analyses were conducted following dialysis. In addition, routine laboratory and 3-d dietary data were obtained. The adequate intake (AI) cut-off for n-3 PUFAs was 1.6 g/d and 1.1 g/d for male and female patients, respectively. Results: The average age of the participants was 63.0 ± 10.4 y. The mean ratios of n-3/n-6 PUFA intake, n-6/n-3 PUFA intake, SMM, and ASM of the patients were 0.13 ± 0.07, 9.4 ± 6.4, 24.6 ± 5.4 kg, and 18.3 ± 4.6 kg, respectively. Patients who had AI of n-3 PUFAs had significantly higher SMM and ASM than did their counterparts. Linear and stepwise multivariable adjustment analyses revealed that insulin resistance and the n-6/n-3 PUFA ratio were the independent deleterious determinants of ASM normalized to height in HD patients. Conclusions: Patients with AI of n-3 PUFAs had total-body SMM and ASM that were more appropriate. A higher dietary ratio of n-6/n-3 PUFAs was associated with reduced muscle mass in HD patients.
KW - Appendicular skeletal muscle mass
KW - Diabetes
KW - Hemodialysis
KW - Polyunsaturated fatty acids
KW - Skeletal muscle mass
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U2 - 10.1016/j.nut.2016.02.015
DO - 10.1016/j.nut.2016.02.015
M3 - Article
C2 - 27157471
AN - SCOPUS:84964814878
SN - 0899-9007
VL - 32
SP - 989
EP - 994
JO - Nutrition
JF - Nutrition
IS - 9
ER -