Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)

ShioShin Jean; Wen-Sen Lee; Kwok Woon Yu; Chun Hsing Liao; Chin-Wung Hsu; Feng Yi Chang; Wen Chien Ko; Ray-Jade Chen; Jiunn Jong Wu; Yen Hsu Chen; Yao Shen Chen; Jien Wei Liu; Min Chi Lu; Carlos Lam; Cheng Yi Liu; Po Ren Hsueh

doi:10.1016/j.jmii.2014.12.008

Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)

ShioShin Jean, Wen-Sen Lee, Kwok Woon Yu, Chun Hsing Liao, Chin-Wung Hsu, Feng Yi Chang, Wen Chien Ko, Ray-Jade Chen, Jiunn Jong Wu, Yen Hsu Chen, Yao Shen Chen, Jien Wei Liu, Min Chi Lu, Carlos Lam, Cheng Yi Liu, Po Ren Hsueh

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Background: Data on susceptibility to ceftobiprole and colistin, and the complete evolutionary trends of minimum inhibitory concentrations (MICs) of important carbapenem agents among important pathogens collected in intensive care units (ICUs) in Taiwan are lacking. Methods: We surveyed the MIC distribution patterns of ceftobiprole and colistin and susceptibility profiles of some important pathogens collected from patients hospitalized in intensive care units (ICUs) of major teaching hospitals throughout Taiwan in 2007. We also investigated the rates of nonsusceptibility to powerful carbapenems (imipenem, meropenem) among four important species of Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Proteus mirabilis) collected during the same period. MIC breakpoints recommended by the Clinical and Laboratory Standards Institute in 2014 were applied. Results: Colistin showed excellent invitro activity (susceptibility rate, 96%) against Acinetobacter baumannii isolates but moderate (73-77% susceptibility rate) activity against isolates of Pseudomonas aeruginosa and E. cloacae. The ceftobiprole MIC₉₀ value was 4μg/mL for methicillin-resistant Staphylococcus aureus and 16μg/mL for P. aeruginosa. The phenotype of methicillin resistance did not markedly increase the MIC value of ceftobiprole among S. aureus isolates. Interestingly, the proportion of isolates that displayed nonsusceptibility to imipenem was significantly higher among P. mirabilis isolates than among isolates of the other three Enterobacteriaceae species, regardless of the production of extended-spectrum β-lactamase. Conclusion: Continuous monitoring of susceptibility profiles of ICU pathogens to important antibiotics is warranted to provide appropriate antimicrobial regimens against infections in the ICU.

Original language	English
Pages (from-to)	969-976
Number of pages	8
Journal	Journal of Microbiology, Immunology and Infection
Volume	49
Issue number	6
DOIs	https://doi.org/10.1016/j.jmii.2014.12.008
Publication status	Published - Dec 1 2016

Keywords

carbapenem
ceftobiprole
colistin
intensive care unit
nonsusceptibility

ASJC Scopus subject areas

Immunology and Allergy
General Immunology and Microbiology
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Jean, S., Lee, W.-S., Yu, K. W., Liao, C. H., Hsu, C.-W., Chang, F. Y., Ko, W. C., Chen, R.-J., Wu, J. J., Chen, Y. H., Chen, Y. S., Liu, J. W., Lu, M. C., Lam, C., Liu, C. Y., & Hsueh, P. R. (2016). Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART). Journal of Microbiology, Immunology and Infection, 49(6), 969-976. https://doi.org/10.1016/j.jmii.2014.12.008

Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART). / Jean, ShioShin; Lee, Wen-Sen; Yu, Kwok Woon et al.
In: Journal of Microbiology, Immunology and Infection, Vol. 49, No. 6, 01.12.2016, p. 969-976.

Research output: Contribution to journal › Article › peer-review

Jean, S, Lee, W-S, Yu, KW, Liao, CH, Hsu, C-W, Chang, FY, Ko, WC, Chen, R-J, Wu, JJ, Chen, YH, Chen, YS, Liu, JW, Lu, MC, Lam, C, Liu, CY & Hsueh, PR 2016, 'Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)', Journal of Microbiology, Immunology and Infection, vol. 49, no. 6, pp. 969-976. https://doi.org/10.1016/j.jmii.2014.12.008

Jean S, Lee WS, Yu KW, Liao CH, Hsu CW, Chang FY et al. Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART). Journal of Microbiology, Immunology and Infection. 2016 Dec 1;49(6):969-976. doi: 10.1016/j.jmii.2014.12.008

Jean, ShioShin ; Lee, Wen-Sen ; Yu, Kwok Woon et al. / Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007 : Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART). In: Journal of Microbiology, Immunology and Infection. 2016 ; Vol. 49, No. 6. pp. 969-976.

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abstract = "Background: Data on susceptibility to ceftobiprole and colistin, and the complete evolutionary trends of minimum inhibitory concentrations (MICs) of important carbapenem agents among important pathogens collected in intensive care units (ICUs) in Taiwan are lacking. Methods: We surveyed the MIC distribution patterns of ceftobiprole and colistin and susceptibility profiles of some important pathogens collected from patients hospitalized in intensive care units (ICUs) of major teaching hospitals throughout Taiwan in 2007. We also investigated the rates of nonsusceptibility to powerful carbapenems (imipenem, meropenem) among four important species of Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Proteus mirabilis) collected during the same period. MIC breakpoints recommended by the Clinical and Laboratory Standards Institute in 2014 were applied. Results: Colistin showed excellent invitro activity (susceptibility rate, 96%) against Acinetobacter baumannii isolates but moderate (73-77% susceptibility rate) activity against isolates of Pseudomonas aeruginosa and E. cloacae. The ceftobiprole MIC90 value was 4μg/mL for methicillin-resistant Staphylococcus aureus and 16μg/mL for P. aeruginosa. The phenotype of methicillin resistance did not markedly increase the MIC value of ceftobiprole among S. aureus isolates. Interestingly, the proportion of isolates that displayed nonsusceptibility to imipenem was significantly higher among P. mirabilis isolates than among isolates of the other three Enterobacteriaceae species, regardless of the production of extended-spectrum β-lactamase. Conclusion: Continuous monitoring of susceptibility profiles of ICU pathogens to important antibiotics is warranted to provide appropriate antimicrobial regimens against infections in the ICU.",

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author = "ShioShin Jean and Wen-Sen Lee and Yu, {Kwok Woon} and Liao, {Chun Hsing} and Chin-Wung Hsu and Chang, {Feng Yi} and Ko, {Wen Chien} and Ray-Jade Chen and Wu, {Jiunn Jong} and Chen, {Yen Hsu} and Chen, {Yao Shen} and Liu, {Jien Wei} and Lu, {Min Chi} and Carlos Lam and Liu, {Cheng Yi} and Hsueh, {Po Ren}",

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T1 - Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007

T2 - Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)

AU - Jean, ShioShin

AU - Lee, Wen-Sen

AU - Yu, Kwok Woon

AU - Liao, Chun Hsing

AU - Hsu, Chin-Wung

AU - Chang, Feng Yi

AU - Ko, Wen Chien

AU - Chen, Ray-Jade

AU - Wu, Jiunn Jong

AU - Chen, Yen Hsu

AU - Chen, Yao Shen

AU - Liu, Jien Wei

AU - Lu, Min Chi

AU - Lam, Carlos

AU - Liu, Cheng Yi

AU - Hsueh, Po Ren

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background: Data on susceptibility to ceftobiprole and colistin, and the complete evolutionary trends of minimum inhibitory concentrations (MICs) of important carbapenem agents among important pathogens collected in intensive care units (ICUs) in Taiwan are lacking. Methods: We surveyed the MIC distribution patterns of ceftobiprole and colistin and susceptibility profiles of some important pathogens collected from patients hospitalized in intensive care units (ICUs) of major teaching hospitals throughout Taiwan in 2007. We also investigated the rates of nonsusceptibility to powerful carbapenems (imipenem, meropenem) among four important species of Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Proteus mirabilis) collected during the same period. MIC breakpoints recommended by the Clinical and Laboratory Standards Institute in 2014 were applied. Results: Colistin showed excellent invitro activity (susceptibility rate, 96%) against Acinetobacter baumannii isolates but moderate (73-77% susceptibility rate) activity against isolates of Pseudomonas aeruginosa and E. cloacae. The ceftobiprole MIC90 value was 4μg/mL for methicillin-resistant Staphylococcus aureus and 16μg/mL for P. aeruginosa. The phenotype of methicillin resistance did not markedly increase the MIC value of ceftobiprole among S. aureus isolates. Interestingly, the proportion of isolates that displayed nonsusceptibility to imipenem was significantly higher among P. mirabilis isolates than among isolates of the other three Enterobacteriaceae species, regardless of the production of extended-spectrum β-lactamase. Conclusion: Continuous monitoring of susceptibility profiles of ICU pathogens to important antibiotics is warranted to provide appropriate antimicrobial regimens against infections in the ICU.

AB - Background: Data on susceptibility to ceftobiprole and colistin, and the complete evolutionary trends of minimum inhibitory concentrations (MICs) of important carbapenem agents among important pathogens collected in intensive care units (ICUs) in Taiwan are lacking. Methods: We surveyed the MIC distribution patterns of ceftobiprole and colistin and susceptibility profiles of some important pathogens collected from patients hospitalized in intensive care units (ICUs) of major teaching hospitals throughout Taiwan in 2007. We also investigated the rates of nonsusceptibility to powerful carbapenems (imipenem, meropenem) among four important species of Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Proteus mirabilis) collected during the same period. MIC breakpoints recommended by the Clinical and Laboratory Standards Institute in 2014 were applied. Results: Colistin showed excellent invitro activity (susceptibility rate, 96%) against Acinetobacter baumannii isolates but moderate (73-77% susceptibility rate) activity against isolates of Pseudomonas aeruginosa and E. cloacae. The ceftobiprole MIC90 value was 4μg/mL for methicillin-resistant Staphylococcus aureus and 16μg/mL for P. aeruginosa. The phenotype of methicillin resistance did not markedly increase the MIC value of ceftobiprole among S. aureus isolates. Interestingly, the proportion of isolates that displayed nonsusceptibility to imipenem was significantly higher among P. mirabilis isolates than among isolates of the other three Enterobacteriaceae species, regardless of the production of extended-spectrum β-lactamase. Conclusion: Continuous monitoring of susceptibility profiles of ICU pathogens to important antibiotics is warranted to provide appropriate antimicrobial regimens against infections in the ICU.

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KW - colistin

KW - intensive care unit

KW - nonsusceptibility

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Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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