Rapidly in situ forming hydrophobically-modified chitosan hydrogels via pH-responsive nanostructure transformation

Ya Ling Chiu; Mei Chin Chen; Chun Yu Chen; Po Wei Lee; Fwu Long Mi; U. Ser Jeng; Hsin Lung Chen; Hsing Wen Sung

doi:10.1039/b818906d

Rapidly in situ forming hydrophobically-modified chitosan hydrogels via pH-responsive nanostructure transformation

Ya Ling Chiu, Mei Chin Chen, Chun Yu Chen, Po Wei Lee, Fwu Long Mi, U. Ser Jeng, Hsin Lung Chen, Hsing Wen Sung

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

A pH-responsive hydrogel targeted for various biomedical applications has been developed using a naturally-abundant biopolymer, chitosan, with controlled grafting of hydrophobic side chains. The rapid hydrogelation is driven by a transformation of the nanostructure of the side-chain aggregates from local micelles to interconnected nanodomains in a sponge phase due to the dominance of hydrophobic interaction near physiological pH.

Original language	English
Pages (from-to)	962-965
Number of pages	4
Journal	Soft Matter
Volume	5
Issue number	5
DOIs	https://doi.org/10.1039/b818906d
Publication status	Published - 2009
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)
Condensed Matter Physics

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10.1039/b818906d

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abstract = "A pH-responsive hydrogel targeted for various biomedical applications has been developed using a naturally-abundant biopolymer, chitosan, with controlled grafting of hydrophobic side chains. The rapid hydrogelation is driven by a transformation of the nanostructure of the side-chain aggregates from local micelles to interconnected nanodomains in a sponge phase due to the dominance of hydrophobic interaction near physiological pH.",

author = "Chiu, {Ya Ling} and Chen, {Mei Chin} and Chen, {Chun Yu} and Lee, {Po Wei} and Mi, {Fwu Long} and Jeng, {U. Ser} and Chen, {Hsin Lung} and Sung, {Hsing Wen}",

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AU - Chiu, Ya Ling

AU - Chen, Mei Chin

AU - Chen, Chun Yu

AU - Lee, Po Wei

AU - Mi, Fwu Long

AU - Jeng, U. Ser

AU - Chen, Hsin Lung

AU - Sung, Hsing Wen

PY - 2009

Y1 - 2009

N2 - A pH-responsive hydrogel targeted for various biomedical applications has been developed using a naturally-abundant biopolymer, chitosan, with controlled grafting of hydrophobic side chains. The rapid hydrogelation is driven by a transformation of the nanostructure of the side-chain aggregates from local micelles to interconnected nanodomains in a sponge phase due to the dominance of hydrophobic interaction near physiological pH.

AB - A pH-responsive hydrogel targeted for various biomedical applications has been developed using a naturally-abundant biopolymer, chitosan, with controlled grafting of hydrophobic side chains. The rapid hydrogelation is driven by a transformation of the nanostructure of the side-chain aggregates from local micelles to interconnected nanodomains in a sponge phase due to the dominance of hydrophobic interaction near physiological pH.

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DO - 10.1039/b818906d

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Rapidly in situ forming hydrophobically-modified chitosan hydrogels via pH-responsive nanostructure transformation

Abstract

ASJC Scopus subject areas

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